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A schizophrenia gene locus on chromosome 17q21 in a new set of families of mexican and central american ancestry: evidence from the NIMH genetics of schizophrenia in latino populations study
(Am J Psychiatry 2009;166:442-449, 2009-02-02)
The present study investigated a new set of families of Latin American ancestry in order to detect the location of genes predisposing to schizophrenia and related psychotic disorders. Method: A genome-wide scan was performed ...
In vivo and in vitro genetic evidence of involvement of neuregulin 1 in immune system dysregulation
(J Mol Med (Berl). 2010 November ; 88(11): 1133–1141, 2010-11)
Neuregulin 1 (NRG1) has been implicated in several disorders including breast cancer, multiple sclerosis, and schizophrenia. Also, recent evidence suggests that NRG1 may play a role in regulation of inflammation and immune ...
The epsin 4 gene is associated with psychotic disorders in families of Latin American origin
(Schizophrenia Research vol. 106, num 2 (2008) 253–257, 2008-10-20)
This study attempted to replicate evidence for association of the Epsin 4 gene (which encodes
enthoprotin, a protein involved in vesicular transport) to schizophrenia in a new sample of
families segregating schizophrenia ...
Resultados de la categorización de una muestra de pacientes con diagnóstico de egreso de esquizofrenia
(Acta Médica Costarricense, abril-junio 2002, vol 44 (2), 2002-04)
La esquizofrenia es una enfermedad que afecta aproximadamente al 1% de la población mundial. Es
una de las enfermedades psiquiátricas más debilitantes con un alto costo económico, social, familiar y personal.
En Costa ...
Meta-analysis of 32 genome-wide linkage studies of schizophrenia
(Molecular Psychiatry (2008), 1–12, Nature Publishing Group, 2008-12-30)
A genome scan meta analysis (GSMA) was carried out on 32 independent genome-wide linkage scan analyses that included 3255 pedigrees with 7413 genotyped cases affected with schizophrenia (SCZ) or related disorders. The ...
Suggestive evidence for association between L-type voltage-gated calcium channel (CACNA1C) gene haplotypes and bipolar disorder in latinos: a family-based association study
(Bipolar Disorders 2013: 15: 206–214, 2013-02-25)
Objectives: Through recent genome-wide association studies (GWASs),
several groups have reported significant association between variants in
the calcium channel, voltage-dependent, L-type, alpha 1C subunit
(CACNA1C) and ...
The serotonin transporter 5-HTTPR polymorphism is associated with current and lifetime depression in persons with chronic psychotic disorders
(Acta Psychiatr Scand 2009: 119: 117–127, 2009-01-11)
Objective: Variation in the serotonin transporter gene (SLC6A4)
promoter region has been shown to influence depression in persons
who have been exposed to a number of stressful life events.
Method: We evaluated whether ...