Universidad de Costa Rica
  • Sobre Kérwá
  • Acceso Abierto
  • Cómo Depositar
  • Políticas
  • Contacto
    • español
    • English
  • English 
    • español
    • English
  • Login
View Item 
  •   Kérwá Home
  • Investigación
  • Salud
  • Medicina, ciencias biomédicas y salud pública
  • View Item
  •   Kérwá Home
  • Investigación
  • Salud
  • Medicina, ciencias biomédicas y salud pública
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

In vivo and in vitro genetic evidence of involvement of neuregulin 1 in immune system dysregulation

artículo científico
Thumbnail
View/Open
In vivo and in vitro genetic evidence of involvement of neuregulin 1 in inmune system dysregulation.pdf (496.7Kb)
Date
2010-11
Author
Marballi, Ketan
Quiñones, Marlon
Jiménez, Fabio
Escamilla, Michael
Raventós Vorst, Henriette
Soto Bernardini, María Clara
Ahuja, Seema S.
Walss Bass, Consuelo
Metadata
Show full item record
Abstract
Neuregulin 1 (NRG1) has been implicated in several disorders including breast cancer, multiple sclerosis, and schizophrenia. Also, recent evidence suggests that NRG1 may play a role in regulation of inflammation and immune system response. We therefore hypothesized that a schizophrenia-associated missense mutation (valine to leucine) we identified within the transmembrane region of NRG1 would also be linked to immune dysregulation. We used plasma samples from families carrying the mutation to measure levels of antibodies to 41 autoimmune markers and six cytokines (IL-1b, IL-6, IL-10, IL-8, IL-12p70, and TNF-α) and used these levels Epstein–Barr virus-transformed B cells from heterozygous mutation carriers and wild-type individuals to evaluate protein and mRNA cytokine expression in vitro using quantitative PCR and ELISA assays. In vivo, increased levels of 25 autoimmune markers as well as elevated levels of cytokines were significantly associated with the NRG1 mutation. In vitro, we observed a significant increase in protein secretion levels of IL-6, TNF-α, and IL-8 in mutation carriers compared with controls. At the mRNA level, we observed a significant increase in IL-6 expression, while IL-4 levels appeared to be downregulated in heterozygous individuals compared with wild-type controls. This is the first report of association of a NRG1 mutation with immune dysregulation. This study could contribute towards understanding the role of NRG1 in the pathogenesis of schizophrenia and other disorders in which inflammation plays an important role.
URI
https://hdl.handle.net/10669/11056
External link to the item
10.1007/s00109-010-0653-y
http://link.springer.com/article/10.1007/s00109-010-0653-y
artículo (arbitrado) -- Universidad de Costa Rica. Centro de Investigaciones en Biología Celular y Molecular, 2010
 
Collections
  • Medicina, ciencias biomédicas y salud pública [1679]



  • Repositorios universitarios

  • Repositorio del SIBDI-UCR
  • Biblioteca Digital del CIICLA
  • Repositorio Documental Rafael Obregón Loría (CIHAC)
  • Biblioteca Digital Carlos Melendez (CIHAC)
  • Repositorio de Fotografías
  • Colección de videos de UPA-VAS
  • Sitios recomendados

  • Buscador regional de LA Referencia
  • Buscador del Open ROAR
  • Scientific Electronic Library Online (SciELO)
  • Directory of Open Access Journals (DOAJ)
  • Redalyc
  • Redes sociales

  • facebook.com/repositoriokerwa
  • @Ciencia_UCR
  • Sobre Kérwá
  • Acceso Abierto
  • Cómo depositar
  • Políticas
Contact Us | Send Feedback
Repositorio Institucional de la Universidad de Costa Rica. Algunos derechos reservados. Este repositorio funciona con DSpace.
 

 

Browse

All of KérwáCommunities & CollectionsTitlesAuthorsSubjectsProcedenceTypeThis CollectionTitlesAuthorsSubjectsProcedenceType

My Account

LoginRegister

  • Repositorios universitarios

  • Repositorio del SIBDI-UCR
  • Biblioteca Digital del CIICLA
  • Repositorio Documental Rafael Obregón Loría (CIHAC)
  • Biblioteca Digital Carlos Melendez (CIHAC)
  • Repositorio de Fotografías
  • Colección de videos de UPA-VAS
  • Sitios recomendados

  • Buscador regional de LA Referencia
  • Buscador del Open ROAR
  • Scientific Electronic Library Online (SciELO)
  • Directory of Open Access Journals (DOAJ)
  • Redalyc
  • Redes sociales

  • facebook.com/repositoriokerwa
  • @Ciencia_UCR
  • Sobre Kérwá
  • Acceso Abierto
  • Cómo depositar
  • Políticas
Contact Us | Send Feedback
Repositorio Institucional de la Universidad de Costa Rica. Algunos derechos reservados. Este repositorio funciona con DSpace.