The serotonin transporter 5-HTTPR polymorphism is associated with current and lifetime depression in persons with chronic psychotic disorders
Contreras Rojas, Javier
Glahn, David C.
Mendoza Rodríguez, Ricardo
Raventós Vorst, Henriette
Ontiveros Sánchez de la Barquera, Jose Alfonso
Nicolini Sánchez, José Humberto
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Objective: Variation in the serotonin transporter gene (SLC6A4) promoter region has been shown to influence depression in persons who have been exposed to a number of stressful life events. Method: We evaluated whether genetic variation in 5-HTTLPR, influences current depression, lifetime history of depression and quantitative measures of depression in persons with chronic psychotic disorders. This is an association study of a genetic variant with quantitative and categorical definitions of depression conducted in the southwest US, Mexico and Costa Rica. We analyzed 260 subjects with a history of psychosis, from a sample of 129 families. Results: We found that persons carrying at least one short allele had a statistically significant increased lifetime risk for depressive syndromes (P < 0.02, odds ratio 2.18, 95% CI 1.10–4.20). Conclusion: The ss or sl genotype at the 5-HTTLPR promoter polymorphic locus increases the risk of psychotic individuals to develop major depression during the course of their illness.
External link to the item10.1111/j.1600-0447.2008.01273.x
artículo (arbitrado) -- Universidad de Costa Rica, Centro de Investigaciones en Biología Celular y Molecular. 2008