Browsing Microbiología by Title
Now showing items 229-248 of 1169
-
Characterization of aspercetin, a platelet aggregating component from the venom of the snake Bothrops asper which induces thrombocytopenia and potentiates metalloproteinase-induced hemorrhage
(2001-04)Thrombocytopenia occurs in a number of patients bitten by Bothrops asper, a species responsible for the majority of snakebites in Central America and southern Mexico. In this work we describe the isolation of a new ... -
Characterization of events associated with apoptosis/anoikis induced by snake venom metalloproteinase BaP1 on human endothelial cells
(2005-02)Human endothelial EA.hy926 cells were incubated with BaP1, a hemorrhagic metalloproteinase purified from Bothrops asper snake venom. Since the first hour of incubation with the proteinase, cells started showing DNA ... -
Characterization of Extracellular Vesicles Secreted by a Clinical Isolate of Naegleria fowleri and Identification of Immunogenic Components within Their Protein Cargo
(2022-06)Abstract: Extracellular vesicles (EVs) are small lipid vesicles released by both prokaryotic and eu-karyotic cells, involved in intercellular communication, immunomodulation and pathogenesis. In this study, we performed a ... -
Characterization of heterogeneous response to chemotherapy by perturbation-based modeling of fluorescent sphingolipid metabolism in cancer cell subpopulations
(2017)Cancer treatments options are limited by the generation of therapy resistance, which is due by intratumoral heterogeneity in cell response. The study of resistance requires biosensors able to report the response at the ... -
Characterization of the local tissue damage induced by LHF-II, a metalloproteinase with weak hemorrhagic activity isolated from Lachesis muta muta snake venom
(1999-09)Local tissue damage induced by LHF-II, a 22-kDa hemorrhagic metalloproteinase from Lachesis muta venom was studied. Intravital microscopy experiments evidenced hemorrhagic events 2 min after LHF-II application onto cremaster ... -
Chemical modification of histidine and lysine residues of myotoxic phospholipases A2 isolated from Bothrops asper and Bothrops godmani snake venoms: effects on enzymatic and pharmacological properties
(1997-02)Lysine and histidine residues of two myotoxic phospholipases A2, Bothrops asper myotoxin III and Bothrops godmani myotoxin I, were chemically modified in order to study the effects of these treatments on enzymatic and ... -
Chikungunya: un virus que nos acecha
(2015-06-01)El virus chikungunya representa una amenaza para Costa Rica. Este arbovirus ha sido introducido al continente americano desde finales de 2013. Debido a sus características epidemiológicas y virológicas, y a la presencia ... -
Cimex lectularius Linnaeus, 1758 (Hemiptera: Cimicidae) in Costa Rica: First Case Report Confirmed by Molecular Methods in Central America
(2020)Cimex lectularius and Cimex hemipterus are the most common species of bedbugs that infest homes. Although case reports decreased substantially by the end of the 20th century, bed bugs, and especially C. lectularius, are ... -
Las citokinas, elementos centrales para la comprensión y manipulación terapéutica del sistema inmune (Parte 1)
(1995)Dentro del explosivo desarrollo en que se encuentra la inmunología básica, el campo de las citokinas y sus funciones dentro (y fuera) del sistema inmune, es uno de los que crece más vertiginosamente. En la primera parte ... -
Las citokinas, elementos centrales para la comprensión y manipulación terapéutica del sistema inmune (Parte II)
(1996)Las citokinas están interrelacionadas en una red funcional, la cual está finamente regulada. El balance en la producción de estas proteínas va a jugar un papel determinante en dirigir al sistema inmune hacia un determinado ... -
ClC-1 Chloride channel: Inputs on the structure–function relationship of myotonia congenita-causing mutations
(2023)Myotonia congenita is a hereditary muscle disease mainly characterized by muscle hyperexcitability, which leads to a sustained burst of discharges that correlates with the magnitude and duration of involuntary aftercontractions, ... -
Cleavage of the NH2-Terminal Octapeptide of Bothrops asper Myotoxic Lysine-49 Phospholipase A2 Reduces Its Membrane-Destabilizing Effect
(1994-08)Bothrops asper myotoxin II was cleaved with cyanogen bromide to determine the role of NH2-terminal amino acid residues in its ability to destabilize negatively charged liposomes and to induce myonecrosis. After treatment, ... -
Clinical and laboratory alterations in horses during immunization with snake venoms for the production of polyvalent (Crotalinae) antivenom
(1997-01)Six horses were immunized with the venoms of Bothrops asper, Crotalus durissus durissus and Lachesis muta stenophrys for the production of polyvalent (Crotalinae) antivenom. During the immunization, clinical and laboratory ... -
Clinical profiles at the time of diagnosis of COVID-19 in Costa Rica during the pre-vaccination period using a machine learning approach
(2021)Background: The clinical manifestations of COVID-19 disease, caused by the SARS-CoV-2 virus, define a large spectrum of symptoms that are mainly dependent on the human host conditions. In Costa Rica, almost 319 000 cases ... -
Cloning, purification and characterization of nigrelysin, a novel actinoporin from the sea anemone Anthopleura nigrescens
(2019)Actinoporins constitute a unique class of pore-forming toxins found in sea anemones that being secreted as soluble monomers are able to bind and permeabilize membranes leading to cell death. The interest in these proteins ... -
Clostridium perfringens Phospholipase C, an Archetypal Bacterial Virulence Factor, induces the Formation of Extracellular Traps by Human Neutrophils
(2023)Neutrophil extracellular traps (NETs) are networks of DNA and various microbicidal proteins, released to the extracellular space to kill invading microorganisms and prevent their dissemination. However, a NETs excess is ... -
CMV-encoded Fcγ receptors: modulators at the interface of innate and adaptive immunity
(2014-10-07)The constant region of IgG antibodies mediates antiviral activities upon engaging host Fcγ receptors (FcγRs) expressed by a variety of immune cells, such as antibody-dependent cellullar cytotoxcity (ADCC) executed by natural ... -
Coinfecciones bacterianas asociadas a la infección por el virus SARS-CoV-2 y su efecto en la resistencia antimicrobiana
(2023-07)El virus del SARS-CoV-2 con su consecuente cuadro clínico de COVID-19, surgió en China a finales del 2019. En marzo del 2020 se declaró pandemia y se extendió por aproximadamente tres años. En los casos severos de enfermedad ... -
Combined venom gland cDNA sequencing and venomics of the New Guinea small-eyed snake, Micropechis ikaheka
(2014-10-14)The venom arsenal of the New Guinea small-eyed snake, Micropechis ikaheka, was investigated by a joint cDNA sequencing and venomics approach. Twenty-seven full-length DNA sequences encoding novel venom proteins were recovered ...