Molecular characterization of a region of DNA associated with mutations at the agouti locus in the mouse
Date
Authors
Bultman, S. J.
Russell, L. B.
Gutiérrez Espeleta, Gustavo A.
Woychik, R.P.
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Abstract
Molecular characterization of a radiationinduced
agouti (a)-locus mutation has resulted in the isolation
of a segment of DNA that maps at or near the a locus on
chromosome 2 in the mouse. This region of DNA is deleted in
several radiation- or chemical-induced homozygous-lethal alocus
mutations and is associated with specific DNA structural
alterations in two viable a-locus mutations. We propose that
DNA probes from this region of chromosome 2 will be useful for
ultimately characterizing the individual gene or genes associated
with a-locus function.
Description
Artículo científico -- Universidad de Costa Rica, Instituto de Investigaciones en Salud. 1991
Keywords
agouti locus, mutaciones geneticas, estructura genética