Mouse determinant lethal and bone marrow micronucleus studies on methyl vinyl sulfone and divinyl sulfone
Loading...
Date
Authors
Shelby, Michael D.
Gutiérrez Espeleta, Gustavo A.
Generoso, Walderico M.
Mcfee, A. F.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Methyl vinyl sulfone and divinyl sulfone were tested for the induction of dominant lethal mutations and micronucleated bone-marrow erythrocytes in male mice. These chemicals were chosen for study because of their similarities in structure and chemical reactivity to acrylamide which is known to induce both effects. Following administration of the test compounds by intraperitoneal injection at the maximum tolerated doses, no evidence of induced dominant lethal mutations or micronucleated bone-marrow cells was observed for either chemical. It is concluded that structures and Michael reactivities similar to acrylamide are not sufficient to impart similar in vivo genetic toxicity to MVS and DVS.
Description
Artículo científico-- Instituto de Investigaciones en Salud-- 1991. La revista no permite distribuir la versión final del documento.
Keywords
Methyl vinyl sulphone, Divinyl sulphone, Dominant lethal mutations, Bone marrow erythrocytes, Micronucleus studies, Acryiamide
Citation
http://www.journals.elsevier.com/mutation-research-genetic-toxicology-and-environmental-mutagenesis/