Manifestaciones bucales de la enfermedad celiaca y alergia al trigo: Reporte de tres casos y revisión literatura
Fecha
2018
Tipo
artículo original
Autores
Boza Oreamuno, Yadira Vanessa
Rugama Flores, María Fernanda
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Resumen
La Enfermedad Celíaca (EC) es una enfermedad sistémica inmunomediada, provocada por el gluten
y prolaminas relacionadas, en individuos genéticamente susceptibles. Se caracteriza por manifestaciones
clínicas dependientes del gluten, anticuerpos específicos de EC, haplotipos HLA DQ2 o DQ8 y enteropatía.
La mayoría de los pacientes son asintomáticos o con manifestaciones leves. Afecta principalmente
el sistema gastrointestinal causando síntomas y signos como diarrea, dolor abdominal recurrente y
distensión abdominal; además manifestaciones extradigestivas. Los pacientes con EC pueden tener
manifestaciones bucales que incluyen estomatitis aftosa recurrente (EAR), hipoplasia del esmalte,
glositis atrófica, entre otras. El diagnóstico de EC se basa en la historia clínica, serología, endoscopía e
histología. Existen otras entidades que deben diferenciarse de la EC, como la sensibilidad al gluten no
celíaca y la alergia al trigo. El objetivo de este trabajo es presentar tres pacientes con antecedentes de
EAR y otras manifestaciones clínicas asociadas al diagnóstico precoz de EC y alergia alimentaria
Celiac Disease (CD) is an immune-mediated systemic disease, caused by gluten and related prolamins, in genetically susceptible individuals. It is characterized by gluten-dependent clinical manifestations, CD-specific antibodies, HLA DQ2 or DQ8 haplotypes, and enteropathy. Most patients are asymptomatic or with mild manifestations. It mainly affects the gastrointestinal system causing symptoms and signs such as diarrhea, recurrent abdominal pain and abdominal distension; also extradigestive manifestations. Patients with CD may have oral manifestations that include recurrent aphthous stomatitis (RAS), enamel hypoplasia, atrophic glossitis, among others. The diagnosis of CD is based on clinical history, serology, endoscopy and histology. There are other entities that should be differentiated from CD, such as non-celiac gluten sensitivity and wheat allergy. The aim of this study is to present three patients with a history of RAS and other clinical manifestations associated with the early diagnosis of CD and food allergy
Celiac Disease (CD) is an immune-mediated systemic disease, caused by gluten and related prolamins, in genetically susceptible individuals. It is characterized by gluten-dependent clinical manifestations, CD-specific antibodies, HLA DQ2 or DQ8 haplotypes, and enteropathy. Most patients are asymptomatic or with mild manifestations. It mainly affects the gastrointestinal system causing symptoms and signs such as diarrhea, recurrent abdominal pain and abdominal distension; also extradigestive manifestations. Patients with CD may have oral manifestations that include recurrent aphthous stomatitis (RAS), enamel hypoplasia, atrophic glossitis, among others. The diagnosis of CD is based on clinical history, serology, endoscopy and histology. There are other entities that should be differentiated from CD, such as non-celiac gluten sensitivity and wheat allergy. The aim of this study is to present three patients with a history of RAS and other clinical manifestations associated with the early diagnosis of CD and food allergy
Descripción
Palabras clave
Enfermedad celíaca, Alergia al trigo, Manifestaciones orales, Estomatitis aftosa recurrente, Celiac disease, Wheat allergy, Oral manifestations, Recurrent aphthous stomatitis