Synthesis and Evaluation of Aromatic Surfactants as Potential Antibacterial and Cytotoxic Agents
Fecha
2019-01
Tipo
artículo original
Autores
Barrantes Jiménez, Kenia
Fuentes, Mary
Chacón Jiménez, Luz María
Achí Araya, María Rosario
Vázquez Tato, José
Vázquez Tato, María del Pilar
Granados Zúñiga, Jorge
Alvarado, María José
Somarribas Patterson, Luis Felipe
Seijas, Julio A.
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Resumen
Two ether and one ester derivatives of the 4-nitro-3-hydroxybenzoic acid were synthesized
and characterized. The in vitro antimicrobial and cytotoxic activities of the three novel compounds
were also evaluated. The aromatic derivatives showed antibacterial activity against one of the four microorganisms
tested and two compounds (C8 and NOBA) had a lower IC50 in HeLa cells.
Descripción
Palabras clave
Cytotoxic activity, Antimicrobial activity, Aromatic, 4-nitro-3-hidroxybenzoic acid, Surfactants, Organic chemistry, 547 Química orgánica