The Hippo Kinase LATS2 Controls Helicobacter pylori-Induced Epithelial-Mesenchymal Transition and Intestinal Metaplasia in Gastric Mucosa
| dc.creator | Molina Castro, Silvia Elena | |
| dc.creator | Tiffon, Camille | |
| dc.creator | Giraud, Julie | |
| dc.creator | Boeuf, Hélène | |
| dc.creator | Sifré, Elodie | |
| dc.creator | Giese, Alban | |
| dc.creator | Belleannée, Geneviève | |
| dc.creator | Lethours, Philippe | |
| dc.creator | Bessède, Emilie | |
| dc.creator | Mégraud, Francis | |
| dc.creator | Dubus, Pierre | |
| dc.creator | Staedel, Cathy | |
| dc.creator | Varon, Christine | |
| dc.date.accessioned | 2020-12-10T16:24:32Z | |
| dc.date.available | 2020-12-10T16:24:32Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | Gastric carcinoma is related mostly to CagA+-Helicobacter pylori infection, which disrupts the gastric mucosa turnover and elicits an epithelial-mesenchymal transition (EMT) and preneoplastic transdifferentiation. The tumor suppressor Hippo pathway controls stem cell homeostasis; its core, constituted by the large tumor suppressor 2 (LATS2) kinase and its substrate Yes-associated protein 1 (YAP1), was investigated in this context. | es |
| dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones en Salud (INISA) | es |
| dc.identifier.citation | https://www.cmghjournal.org/article/S2352-345X(19)30143-2/fulltext | |
| dc.identifier.doi | https://doi.org/10.1016/j.jcmgh.2019.10.007 | |
| dc.identifier.issn | 2352-345X | |
| dc.identifier.uri | https://hdl.handle.net/10669/82160 | |
| dc.language.iso | en_US | |
| dc.rights | acceso abierto | |
| dc.source | Cellular and Molecular Gastroenterology and Hepatology 9(2) | es |
| dc.subject | YAP1 | es |
| dc.subject | Epithelial-to-Mesenchymal Transition | es |
| dc.subject | Adenocarcinoma | es |
| dc.subject | CagA | es |
| dc.title | The Hippo Kinase LATS2 Controls Helicobacter pylori-Induced Epithelial-Mesenchymal Transition and Intestinal Metaplasia in Gastric Mucosa | es |
| dc.type | artículo original |