The Hippo Kinase LATS2 Controls Helicobacter pylori-Induced Epithelial-Mesenchymal Transition and Intestinal Metaplasia in Gastric Mucosa
Date
Authors
Molina Castro, Silvia Elena
Tiffon, Camille
Giraud, Julie
Boeuf, Hélène
Sifré, Elodie
Giese, Alban
Belleannée, Geneviève
Lethours, Philippe
Bessède, Emilie
Mégraud, Francis
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Gastric carcinoma is related mostly to CagA+-Helicobacter pylori infection, which disrupts the gastric mucosa turnover and elicits an epithelial-mesenchymal transition (EMT) and preneoplastic transdifferentiation. The tumor suppressor Hippo pathway controls stem cell homeostasis; its core, constituted by the large tumor suppressor 2 (LATS2) kinase and its substrate Yes-associated protein 1 (YAP1), was investigated in this context.
Description
Keywords
YAP1, Epithelial-to-Mesenchymal Transition, Adenocarcinoma, CagA