Sekikaic Acid and Lobaric Acid Target a Dynamic Interface of the Coactivator CBP/p300
artículo científico
Fecha
2012-10-08Autor
Majmudar, Chinmay Y.
Højfeldt, Jonas W.
Arevang, Carl J.
Pomerantz, William C.
Gagnon, Jessica K.
Schultz, Pamela J.
Cesa, Laura C.
Doss, Conor H.
Rowe, Steven P.
Vásquez Chaves, Víctor
Tamayo Castillo, Giselle
Cierpicki, Tomasz
Brooks, Charles L. III
Sherman, David H.
Mapp, Anna K.
Metadatos
Mostrar el registro completo del ítemResumen
Although there have been recent notable successes in thediscovery of ligands that target stable, high-affinity protein-protein interactions (PPIs), the transient and moderateaffinity PPIs that underpin many fundamental cellularprocesses have proven to be far less tractable for liganddiscovery.[1]Prime examples of this are the dynamic com-plexes formed between DNA-bound transcriptional activa-tors and coactivators that are part of eukaryotic transcriptioninitiation.
External link to the item
10.1002/ange.201206815Colecciones
- Química [322]