A new method for the preparation of 1,3-dilithiopropyne: an efficient synthesis of homopropargyl alcohols

Fecha

2001

Tipo

artículo original

Autores

Cabezas Pizarro, Jorge A.
Pereira, Albán R. 
Amey, Adam R.

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Resumen

Controlled dilithiation of propargyl bromide with two equivalents of n-butyllithium, in the presence of TMEDA, produces the operational equivalent of the dianion 1,3-dilithiopropyne. The latter reacts efficiently with aldehydes and ketones to produce homopropargyl alcohols in a single step route and in high yields. Controlled dilithiation of propargyl bromide with n-BuLi, in the presence of TMEDA, produces the operational equivalent of the dianion 1,3-dilithiopropyne. The latter reacts efficiently with aldehydes and ketones to produce homopropargyl alcohols in a single step route in high yields.

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CHEMICAL ANALYSIS, CHEMICAL PROCESSES, CHEMISTRY, CHEMICAL ELEMENTS

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