Isolation of Major Components from the Roots of Godmania aesculifolia and Determination of Their Antifungal Activities

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dc.creatorTamayo Castillo, Giselle
dc.creatorVásquez Chaves, Víctor
dc.creatorRíos Marín, María Isabel
dc.creatorRodríguez, María Victoria
dc.creatorSolano Arias, Godofredo
dc.creatorZacchino, Susana Alicia
dc.creatorGupta, Mahabir Prashad
dc.date.accessioned2023-01-02T20:29:37Z
dc.date.available2023-01-02T20:29:37Z
dc.date.issued2013
dc.description.abstractFrom the methanol root extract of Godmania aesculifolia, a species selected in a multinational OAS program aimed at discovering antifungal compounds from Latin American plants, a new chavicol diglycoside (1), the known 3,4-dihydroxy-2-(3-methylbut-2-en-1-yl)-3,4-dihydronaphthalen-1(2H)-one (2), and lapachol (3) were isolated and characterized by 1D and 2D NMR and MS techniques. Only 3 exhibited fairly good activity against a panel of clinical isolates of Cryptococcus neoformans (MIC50 between 7.8 and 31.2 µg/mL) and moderate activities against Candida spp. and non-albicans Candida spp.es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Químicaes_ES
dc.identifier.citationhttps://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0033-1351025es_ES
dc.identifier.doi10.1055/s-0033-1351025
dc.identifier.issn0032-0943
dc.identifier.urihttps://hdl.handle.net/10669/87976
dc.language.isoenges_ES
dc.rightsacceso embargado
dc.sourcePlanta Mediica, vol.79(18), pp.1749-1755es_ES
dc.subjectGodmania aesculifoliaes_ES
dc.subjectBignoniaceaees_ES
dc.subjectlapacholes_ES
dc.subjectChavicol diglycosidees_ES
dc.subjectTrichophyton spp.es_ES
dc.subjectMicrosporum spp.es_ES
dc.subjectAspergillus spp.es_ES
dc.subjectCandidaes_ES
dc.subjectCryptococcus neoformanses_ES
dc.titleIsolation of Major Components from the Roots of Godmania aesculifolia and Determination of Their Antifungal Activitieses_ES
dc.typeartículo originales_ES

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