Isolation of Major Components from the Roots of Godmania aesculifolia and Determination of Their Antifungal Activities
Fecha
2013
Tipo
artículo original
Autores
Tamayo Castillo, Giselle
Vásquez Chaves, Víctor
Ríos Marín, María Isabel
Rodríguez, María Victoria
Solano Arias, Godofredo
Zacchino, Susana Alicia
Gupta, Mahabir Prashad
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Resumen
From the methanol root extract of Godmania aesculifolia, a species selected in a multinational OAS program aimed at discovering antifungal compounds from Latin American plants, a new chavicol diglycoside (1), the known 3,4-dihydroxy-2-(3-methylbut-2-en-1-yl)-3,4-dihydronaphthalen-1(2H)-one (2), and lapachol (3) were isolated and characterized by 1D and 2D NMR and MS techniques. Only 3 exhibited fairly good activity against a panel of clinical isolates of Cryptococcus neoformans (MIC50 between 7.8 and 31.2 µg/mL) and moderate activities against Candida spp. and non-albicans Candida spp.
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Godmania aesculifolia, Bignoniaceae, lapachol, Chavicol diglycoside, Trichophyton spp., Microsporum spp., Aspergillus spp., Candida, Cryptococcus neoformans