Anti-inflarnmatory activity of Urera baccifera (Urticaceae) in Sprague-Dawley rats
| dc.creator | Badilla Baltodano, Beatriz | |
| dc.creator | Mora, Gerardo A. | |
| dc.creator | Lapa, Antonio José | |
| dc.creator | Silva Ernim, José Arthur | |
| dc.date | 2015-05-12 | |
| dc.date.accessioned | 2016-05-03T15:30:30Z | |
| dc.date.available | 2016-05-03T15:30:30Z | |
| dc.description | On a preliminary test, anti-inflammatory and analgesic dose-related activities on rats were observed for the aqueous fraction of Urera baccifera; this extract was bioassay-guided fractionated and the final aqueous fraction was used according the ethnobotanical use. Carrageenan-induced edema (n=6), was used as an assay in the fractionating process. The anti-inflammatory and antinociceptive properties of the final aqueons fraction were studied using in vivo models. For the anti-inflammatory activity rat paw edema (n=6), pleurisy induced by carrageenan (n=6) and ear edema induced by topical croton oil (n=6) models were used, and tail-fIick test (n=6), abdominal constrictions induced by acetic acid (n=6), and formalin test (n=6), were used for the alltillociceptive activity. The tests perfonned showed an inhibition effeet on !eukocyte rnigration, and a reductioll on pleural exudate, as well as dose-dependant peripheral analgesic activity, al a range of 25-100 mglk:g i.p. The final aqueous fraction contains most of the anti-inflammatory activity of the plant U. baccifera. A possibJe mechanism of action is discussed and based on the results we conclude that this plant has a potential. for both anti-inflammalory and analgesic activity al the c1inical level. | en-US |
| dc.description | On a preliminary test, anti-inflammatory and analgesic dose-related activities on rats were observed for the aqueous fraction of Urera baccifera; this extract was bioassay-guided fractionated and the final aqueous fraction was used according the ethnobotanical use. Carrageenan-induced edema (n=6), was used as an assay in the fractionating process. The anti-inflammatory and antinociceptive properties of the final aqueons fraction were studied using in vivo models. For the anti-inflammatory activity rat paw edema (n=6), pleurisy induced by carrageenan (n=6) and ear edema induced by topical croton oil (n=6) models were used, and tail-fIick test (n=6), abdominal constrictions induced by acetic acid (n=6), and formalin test (n=6), were used for the alltillociceptive activity. The tests perfonned showed an inhibition effeet on !eukocyte rnigration, and a reductioll on pleural exudate, as well as dose-dependant peripheral analgesic activity, al a range of 25-100 mglk:g i.p. The final aqueous fraction contains most of the anti-inflammatory activity of the plant U. baccifera. A possibJe mechanism of action is discussed and based on the results we conclude that this plant has a potential. for both anti-inflammalory and analgesic activity al the c1inical level. | es |
| dc.format | application/pdf | |
| dc.identifier | http://revistas.ucr.ac.cr/index.php/rbt/article/view/19085 | |
| dc.identifier.uri | https://hdl.handle.net/10669/26887 | |
| dc.language | eng | |
| dc.publisher | Universidad de Costa Rica | en |
| dc.rights | Copyright (c) 2015 International Journal of Tropical Biology and Conservation | en |
| dc.source | Revista de Biología Tropical/International Journal of Tropical Biology and Conservation; Vol. 47 (3) June 1999; 365-371 | es |
| dc.source | 2215-2075 | |
| dc.source | 0034-7744 | |
| dc.subject | urera baccifera | en |
| dc.subject | anti-illflammatory agent | en |
| dc.subject | analgesic | en |
| dc.subject | antinociceptive | en |
| dc.subject | rat paw edema | en |
| dc.subject | urticaceae | en |
| dc.title | Anti-inflarnmatory activity of Urera baccifera (Urticaceae) in Sprague-Dawley rats | en |
| dc.type | artículo original |