Phenolic compounds as antiangiogenic CMG2 inhibitors from costa rican endophytic fungi

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dc.creatorCao, Shugeng
dc.creatorCryan, Lorna
dc.creatorHabeshian, Kaiane A.
dc.creatorMurillo Cruz, Catalina
dc.creatorTamayo Castillo, Giselle
dc.creatorRogers, Michael S. 
dc.creatorClardy, Jon 
dc.date.accessioned2023-01-02T17:46:38Z
dc.date.available2023-01-02T17:46:38Z
dc.date.issued2012
dc.description.abstractTargeting and inhibiting CMG2 (Capillary Morphogenesis Gene protein 2) represents a new strategy for therapeutic agents for cancer and retinal diseases due to CMG2’s role in blood vessel growth (angiogenesis). A high throughput FRET (Förster Resonance Energy Transfer) assay was developed for the identification of CMG2 inhibitors as anti-angiogenetic agents. Bioassay-guided separation led to the isolation and identification of two new compounds (1 and 2) from CR252M, an endophytic fungus Coccomyces proteae collected from a Costa Rican rainforest, and one known compound (3) from CR1207B (Aurapex penicillata). Secondary in vitro assays indicated anti-angiogenic activity. Compound 3 inhibited the endothelial cell migration at 52 μM, but did not show any endothelial cell antiproliferative effect at 156 μM. The structure of the two new compounds, A (1) and B (2), were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR experiments.es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Químicaes_ES
dc.identifier.citationhttps://www.sciencedirect.com/science/article/pii/S0960894X12009602?via%3Dihubes_ES
dc.identifier.doi10.1016/j.bmcl.2012.07.075
dc.identifier.issn0960-894X
dc.identifier.urihttps://hdl.handle.net/10669/87970
dc.language.isoenges_ES
dc.rightsacceso embargado
dc.sourceBioorganic & Medicinal Chemistry Letters, 22(18), p. 5885-5888.es_ES
dc.subjectMUSHROOMes_ES
dc.subjectCoccomyces proteaees_ES
dc.subjectAurapex penicillataes_ES
dc.subjectCMG2es_ES
dc.subjectPhenolices_ES
dc.subjectCOSTA RICAes_ES
dc.titlePhenolic compounds as antiangiogenic CMG2 inhibitors from costa rican endophytic fungies_ES
dc.typeartículo originales_ES

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