The epsin 4 gene is associated with psychotic disorders in families of Latin American origin
Fecha
2008-10-20
Tipo
artículo original
Autores
Escamilla, Michael
Dae Lee, Byung
Ontiveros Sánchez de la Barquera, Jose Alfonso
Nicolini Sánchez, José Humberto
Mendoza Rodríguez, Ricardo
Muñoz, Rodrigo
Medina, Rolando
Walss Bass, Consuelo
Armas, Regina
Contreras, Salvador
Título de la revista
ISSN de la revista
Título del volumen
Editor
Schizophrenia Research vol. 106, num 2 (2008) 253–257
Resumen
This study attempted to replicate evidence for association of the Epsin 4 gene (which encodes
enthoprotin, a protein involved in vesicular transport) to schizophrenia in a new sample of
families segregating schizophrenia drawn from the Latin American population. 1423 subjects
(767 with a history of psychosis) from 337 Latino families were genotyped using three single
nucleotide polymorphisms (SNPs) spanning the Epsin 4 gene. A family based association test
was utilized to test for association of these SNPs to the phenotypes of psychosis and
schizophrenia. Haplotypes defined by these three SNPs showed significant association to the
phenotype of psychosis in this sample (global p value=0.014, bi-allelic p value=0.047).
Variation in the Epsin 4 gene is significantly associated with psychotic disorder in this Latino
population. This provides additional support for the involvement of enthoprotin in the
pathogenesis of schizophrenia and other psychotic disorders.
Descripción
artículo (arbitrado). Universidad de Costa Rica, Centro de Investigación en Biología Celular y Molecular, 2008. Este artículo es privado debido a limitaciones de derechos de autor.
Palabras clave
Gen Epsin 4, Esquizofrenia, Fenotipo, América Latina, Nucléotido