Acute Hepatic Response to Diet Modification and Exercise-induced Endotoxemia during a Laboratory-based Duathlon
Fecha
2010-01
Tipo
artículo original
Autores
Moncada Jiménez, José
Plaisance, Eric Paul
Araya Ramírez, Felipe
Taylor, James K.
Ratcliff, Lance
Mestek, Michael L.
Grandjean, Peter Walter
Aragón Vargas, Luis Fernando
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Resumen
The purpose of the study was to compare the acute hepatic response to diet modification and
exercise-induced endotoxemia, and to determine if associations exist between liver damage markers, body core
temperature, and IL-6 responses to a laboratory-based duathlon. Eleven moderately-trained healthy males
followed a low-carbohydrate (CHO) and a high CHO diet to change their glycogen stores two-days before
completing a duathlon. Blood samples were obtained at rest, immediately after and 1- and 2-h following the
duathlon for determination of endotoxin-lipopolysaccharide binding protein (LPS-LBP) complex, IL-6, and liver
integrity markers AST, ALT, and AST/ALT ratio. Hydration status and body core temperature were assessed at rest,
during, and after the duathlon. Athletes were more dehydrated and had higher AST/ALT ratios in the lowcompared
to the high-CHO diet trial regardless of the measurement time (p<0.05). IL-6 increased from resting
to immediately after, 1- and 2-h following duathlon regardless of the diet (p<0.05). A higher LPS-LBP complex
concentration was observed from rest to immediately after the duathlon. No significant correlations were found
between LPS-LBP complex levels and body core temperature. In conclusion, athletes on a low-CHO diet showed
higher hepatic structural damage and finished more dehydrated compared to athletes on a high-CHO diet. Body
core temperature and LPS-LBP complex levels were unrelated beyond the increase in body core temperature
explained by exercise. No significant associations were found between body core temperature, IL-6 and LPS-LBP
complex concentrations.
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Palabras clave
human, cytokines, lipopolysaccharide, infammation, exercise, humano, citocinas, lipopolisacárido, ejercicio, inflamación, 796.607 8 Ciclismo y actividades relacionadas