Impact of common cardio-metabolic risk factors on fatal and non-fatal cardiovascular disease in Latin America and the Caribbean: an individual-level pooled analysis of 31 cohort studies

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dc.creatorCohorts Consortium of Latin America and the Caribbean (CC-LAC)
dc.date.accessioned2024-05-30T20:23:37Z
dc.date.available2024-05-30T20:23:37Z
dc.date.issued2021
dc.description.abstractBackground: Estimates of the burden of cardio-metabolic risk factors in Latin America and the Caribbean (LAC) rely on relative risks (RRs) from non-LAC countries. Whether these RRs apply to LAC remains un- known. Methods: We pooled LAC cohorts. We estimated RRs per unit of exposure to body mass index (BMI), systolic blood pressure (SBP), fasting plasma glucose (FPG), total cholesterol (TC) and non-HDL cholesterol on fatal (31 cohorts, n = 168,287) and non-fatal (13 cohorts, n = 27,554) cardiovascular diseases, adjusting for regression dilution bias. We used these RRs and national data on mean risk factor levels to estimate the number of cardiovascular deaths attributable to non-optimal levels of each risk factor. Results: Our RRs for SBP, FPG and TC were like those observed in cohorts conducted in high-income countries; however, for BMI, our RRs were consistently smaller in people below 75 years of age. Across risk factors, we observed smaller RRs among older ages. Non-optimal SBP was responsible for the largest number of attributable cardiovascular deaths ranging from 38 per 10 0,0 0 0 women and 54 men in Peru, to 261 (Dominica, women) and 282 (Guyana, men). For non-HDL cholesterol, the lowest attributable rate was for women in Peru (21) and men in Guatemala (25), and the largest in men (158) and women (142) from Guyana. Interpretation: RRs for BMI from studies conducted in high-income countries may overestimate disease burden metrics in LAC; conversely, RRs for SBP, FPG and TC from LAC cohorts are similar to those esti- mated from cohorts in high-income countries.es_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Sociales::Centro Centroamericano de Población (CCP)es_ES
dc.identifier.citationhttps://www.thelancet.com/journals/lanam/article/PIIS2667-193X(21)00064-8/fulltextes_ES
dc.identifier.doi10.1016/j.lana.2021.100068
dc.identifier.issn2667-193X
dc.identifier.urihttps://hdl.handle.net/10669/91466
dc.language.isoenges_ES
dc.rightsacceso abiertoes_ES
dc.sourceThe Lancet Regional Health - Americas, vol.4, p.1-12es_ES
dc.subjectLATIN AMERICAes_ES
dc.subjectCARDIOVASCULAR DISEASESes_ES
dc.titleImpact of common cardio-metabolic risk factors on fatal and non-fatal cardiovascular disease in Latin America and the Caribbean: an individual-level pooled analysis of 31 cohort studieses_ES
dc.typeartículo originales_ES

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