Single and mixture toxicity of selected pharmaceuticals to the aquatic macrophyte Lemna minor

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dc.creatorRamírez Morales, Didier Daniel
dc.creatorFajardo Romero, Daniela
dc.creatorRodríguez Rodríguez, Carlos E.
dc.creatorCedergreen, Nina
dc.date.accessioned2023-02-02T21:52:40Z
dc.date.available2023-02-02T21:52:40Z
dc.date.issued2022-03-28
dc.description.abstractPlants represent uncommon targets to evaluate pharmaceuticals toxicity. In this work, Lemna minor was employed as a plant model to determine the toxicity of selected pharmaceuticals, and to assay if such toxicity could be predicted by QSAR models based on green algae. Among eight compounds, measurable toxicity was determined for ketoprofen (EC50 = 11.8 ± 1.9 mg/L), fluoxetine (EC50 = 27.0 ± 8.7 mg/L) and clindamycin 2-phosphate (EC50 = 57.7 ± 1.7 mg/L). Even though a correlation of r2 = 0.87 was observed between experimental toxicity towards algae and L. minor, QSAR estimations based on algae data poorly predicted the toxicity of pharmaceuticals on the plant. More experimental data for L. minor are necessary to determine the applicability of these predictions; nonetheless, these results remark the importance of measuring experimental ecotoxicological parameters for individual taxa. The toxicity of pharmaceutical binary mixtures (ketoprofen, fluoxetine and clindamycin) revealed in some cases deviations from the concentration addition model; nonetheless these deviations were small, thus the interactions are unlikely to be of severe biological significance. Moreover, the EC50 concentrations determined for these pharmaceuticals are significantly higher than those detected in the environment, suggesting that acute effects on L. minor would not take place at ecosystem level.es_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro en Investigación en Contaminación Ambiental (CICA)es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[802-B7-508]/UCR/Costa Ricaes_ES
dc.description.sponsorshipUniversidad de Costa Rica/[802-B7-510]/UCR/Costa Ricaes_ES
dc.description.sponsorshipUniversidad de Costa Rica/[802-C1-034]/UCR/Costa Ricaes_ES
dc.description.sponsorshipMinisterio de Ciencia, Innovación, Tecnología y Telecomunicaciones/[FI-097B-17]/MICITT/Costa Ricaes_ES
dc.identifier.citationhttps://link.springer.com/article/10.1007/s10646-022-02537-3es_ES
dc.identifier.codproyecto802-B7-508
dc.identifier.codproyecto802- B8-510
dc.identifier.codproyecto802-C1-034
dc.identifier.doi10.1007/s10646-022-02537-3
dc.identifier.issn1573-3017
dc.identifier.issn0963-9292
dc.identifier.urihttps://hdl.handle.net/10669/88139
dc.language.isoenges_ES
dc.rightsacceso abierto
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.sourceEcotoxicology, vol.31, pp. 714-724es_ES
dc.subjectPHARMACEUTICALSes_ES
dc.subjectBinary mixturees_ES
dc.subjectAlgaees_ES
dc.subjectQSARes_ES
dc.subjectPredictiones_ES
dc.subjectEcotoxicityes_ES
dc.titleSingle and mixture toxicity of selected pharmaceuticals to the aquatic macrophyte Lemna minores_ES
dc.typeartículo originales_ES

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