Ability of the phospholipase A2 inhibitor Varespladib to abrogate or delay lethality induced by neurotoxic snake venoms
| dc.creator | Gutiérrez, José María | |
| dc.creator | Lewin, Matthew | |
| dc.creator | Williams, David | |
| dc.creator | Lomonte, Bruno | |
| dc.date.accessioned | 2025-12-16T22:00:13Z | |
| dc.date.issued | 2020-04-20 | |
| dc.description.abstract | This study investigated the ability of the phospholipase A2 (PLA2) inhibitor Varespladib (LY315920) and its oral prodrug, methyl-Varespladib (LY333013), to abrogate or delay the lethality induced by potent neurotoxic snake venoms in a mouse model. The venoms tested were from Oxyuranus scutellatus, Notechis scutatus, Bungarus multicinctus, and Crotalus durissus terrificus, all known for having potent neurotoxic PLA2s. | |
| dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP) | |
| dc.identifier.doi | https://doi.org/10.1016/j.toxicon.2019.10.069 | |
| dc.identifier.issn | 0041-0101 | |
| dc.identifier.uri | https://hdl.handle.net/10669/103433 | |
| dc.language.iso | eng | |
| dc.rights | acceso restringido | |
| dc.source | Toxicon, 177, supplement 1, 2020 | |
| dc.subject | Neurotoxic venom | |
| dc.subject | Presynaptic PLA2s | |
| dc.subject | Antidote | |
| dc.subject | Lethality | |
| dc.subject | Varespladib (LY315920) | |
| dc.title | Ability of the phospholipase A2 inhibitor Varespladib to abrogate or delay lethality induced by neurotoxic snake venoms | |
| dc.type | póster de congreso |