Ability of the phospholipase A2 inhibitor Varespladib to abrogate or delay lethality induced by neurotoxic snake venoms
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Abstract
This study investigated the ability of the phospholipase A2 (PLA2) inhibitor Varespladib (LY315920) and its oral prodrug, methyl-Varespladib (LY333013), to abrogate or delay the lethality induced by potent neurotoxic snake venoms in a mouse model. The venoms tested were from Oxyuranus scutellatus, Notechis scutatus, Bungarus multicinctus, and Crotalus durissus terrificus, all known for having potent neurotoxic PLA2s.
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Neurotoxic venom, Presynaptic PLA2s, Antidote, Lethality, Varespladib (LY315920)