Actividad gastroprotectora del extracto etanólico de hojas de Licania platypus (Hemsl.) Fritish
Fecha
2017-09-05
Tipo
artículo original
Autores
Orozco Aguilar, Josué
Chavarría Rojas, Marianela
Alvarado Barboza, Gilberth
Cordero García, Ana Eugenia
Morales Acuña, Juan Alberto
Retana Salazar, Axel P.
González Camacho, Sara María
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Resumen
La especie Licania platypus, localmente conocida como “sonzapote” se encuentra ampliamente distribuida en países tropicales. Tradicionalmente, en América Central se han utilizado diferentes partes de la planta para diversos problemas de salud, especialmente gastrointestinales. Objetivo: Investigar la posible actividad antiulcerosa gástrica del extracto etanólico de hojas de Licania platypus. Métodos: Las lesiones gástricas fueron inducidas por los modelos de etanol e indometacina. También, se evaluó el extracto con el modelo modificado de Shay. El extracto se administró por vía oral y se midió el área dañada. Además, se analizaron otros parámetros en el modelo de ligadura pilórica. Resultados: La administración oral de una dosis única del extracto (500 mg/kg) redujo significativamente el área de las lesiones gástricas (p < 0.05) en los modelos de inducción de etanol e indometacina. Además, se observó un incremento significativo en la secreción de moco gástrico en el modelo modificado de Shay (p < 0.05). Conclusión: El extracto etanólico de Licania platypus ejerce un efecto gastroprotector en diferentes modelos de inducción de úlceras agudas. Este trabajo brinda la primera evidencia de especies pertenecientes al género Licania con actividad gastroprotectora y permite promover la realización de estudios para elucidar un mecanismo de acción específico.
Abstract: Licania platypus, locally known as “sonzapote”, is a species distributed in tropical countries. Traditionally, it has been used different anatomical parts in Central America for a variety of health problems, especially gastrointestinal problems. Aim: To investigate the possible gastric antiulcer activity of Licania platypus leaves ethanol extract. Methods: Gastric lesions were induced by ethanol and indomethacin models. Also the extract was evaluated in modified Shay rat model. Licania platypus extract were previously administered orally and stomach lesions were measured. Besides, other parameters were analyzed in pylorus-ligated model. Results: Oral administration of a unique dose of ethanol extract (500 mg/kg) significantly reduced the area of gastric lesions (p < 0.05) on ethanol and indomethacin induction models. Furthermore, it was observed a significant increase of the gastric mucus secretion in modified Shay model (p < 0.05). Conclusion: Licania platypus ethanol extract exerted a gastroprotective effect in different acute ulcer induction models. This work provides the first evidence that species of induction models. This work provides the first evidence that species of Licania genus has gastroprotective activity and permits further studies to elucidate a specific mechanism.
Abstract: Licania platypus, locally known as “sonzapote”, is a species distributed in tropical countries. Traditionally, it has been used different anatomical parts in Central America for a variety of health problems, especially gastrointestinal problems. Aim: To investigate the possible gastric antiulcer activity of Licania platypus leaves ethanol extract. Methods: Gastric lesions were induced by ethanol and indomethacin models. Also the extract was evaluated in modified Shay rat model. Licania platypus extract were previously administered orally and stomach lesions were measured. Besides, other parameters were analyzed in pylorus-ligated model. Results: Oral administration of a unique dose of ethanol extract (500 mg/kg) significantly reduced the area of gastric lesions (p < 0.05) on ethanol and indomethacin induction models. Furthermore, it was observed a significant increase of the gastric mucus secretion in modified Shay model (p < 0.05). Conclusion: Licania platypus ethanol extract exerted a gastroprotective effect in different acute ulcer induction models. This work provides the first evidence that species of induction models. This work provides the first evidence that species of Licania genus has gastroprotective activity and permits further studies to elucidate a specific mechanism.
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Úlcera gástrica, Antiulcerosos, Prostaglandinas, Moco, Antioxidantes, Stomach ulcer, Anti-ulcer agents, Prostaglandins, Mocus, Antioxidants, PLANTA MEDICINAL, MEDICINA TRADICIONAL