Polymorphisms in Genes Coding for HSP-70 Are Associated with Gastric Cancer and Duodenal Ulcer in a Population at High Risk of Gastric Cancer in Costa Rica
Fecha
2013
Tipo
artículo original
Autores
Ferrera Ferrera, Maura
Malespín Bendaña, Wendy Karina
Ramírez Mayorga, Vanessa
González Lutz, María Isabel
Carvajal, Adriana
Une, Clas Allan
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ISSN de la revista
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Editor
Resumen
Background and Aims. Costa Rica has among the highest incidence and mortality rates
for gastric cancer worldwide. The reasons for this are largely unknown. Polymorphisms
of inflammatory response genes including genes encoding heat shock proteins (HSP) have
been shown to be associated with the risk of gastric cancer in some populations. This
study addresses the possible association between the HSP70-2 þ1267 and HSP70-
Hom þ2437 polymorphisms and the risk of developing gastric cancer in a high-risk population
in Costa Rica.
Methods. DNA from 39 individuals diagnosed with gastric cancer, 79 healthy controls,
55 individuals with chronic gastritis and 52 individuals with duodenal ulcer was genotyped
for the polymorphisms HSP70-2 þ1267 and HSP70-Hom þ2437 by RFLP. Logistic
regression analysis was used to determine possible associations with the diagnoses and
lineal regression analysis to determine associations with blood pepsinogen (PGs) levels as
measured by serology.
Results. The GA genotype of HSP70-2 was associated with increased risk of gastric cancer
(OR 5 3.42; 95% CI 5 1.27e9.21; p 5 0.015) and duodenal ulcer (OR 5 2.57; 95%
CI 5 1.03e6.36; p 5 0.042) as compared to the GG genotype. Persons with C carrier
genotypes of HSP70-Hom were significantly less susceptible to gastric cancer than those
with the TT genotype (OR 5 0.29; 95% CI 5 0.09e0.87; p 5 0.027). The C carrier genotype
was associated with lower PGI concentrations but none of the polymorphisms
were associated with PGI/PGII.
Conclusions. Polymorphisms of HSP70 genes are associated with the development of
gastric cancer and duodenal ulcers in a population at high risk for gastric cancer in Costa
Rica.
Descripción
Artículo científico -- Universidad de Costa Rica. Instituto de Investigaciones en Salud, 2013. Este documento es privado debido a limitaciones de derechos de autor.
Palabras clave
Salud pública, gastric cancer, duodenal ulcer, chronic gastritis, single nucleotide polymorphisms., heat shock proteins