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Monoclonal antibodies: A therapeutic option for the treatment of ophthalmic diseases of the eye posterior segment

dc.creatorAyón Chang, Catalina
dc.creatorCastán, Daniel
dc.creatorMora Carmona, Adrián
dc.creatorNaranjo, Dunia
dc.creatorObando, Francini
dc.creatorMora Román, Juan José
dc.date.accessioned2024-07-03T20:43:40Z
dc.date.available2024-07-03T20:43:40Z
dc.date.issued2022-08-31
dc.description.abstractThe eye is an organ that allows us to observe the outside world. Pathologies of the eye's posterior segment, such as glaucoma, macular degeneration, diabetic retinopathy, uveitis, and retinoblastoma, cause vision loss. Traditional treatments consist of applying topical medications that do not penetrate properly or using high doses that generate adverse effects. Different laser surgeries stop the pathology's progression but do not allow visual improvement. So, an alternative is to use monoclonal antibodies, proteins produced by different processes that selectively bind to metabolites associated with diseases, reducing the adverse effects of traditional treatments and improving the application of the drug in the area. The two main molecular targets are TNF (adalimumab, infliximab, and certolizumab pegol) and VEGF (bevacizumab and ranibizumab); other possibilities are under investigation.es_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones Farmacéuticas (INIFAR)es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Farmaciaes_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones Farmacéuticas (INIFAR)es_ES
dc.identifier.doi10.33084/bjop.v5i3.2095
dc.identifier.issn2621-4814
dc.identifier.urihttps://hdl.handle.net/10669/91689
dc.language.isoenges_ES
dc.rightsacceso abiertoes_ES
dc.sourceBorneo Journal of Pharmacy, 5(3), 229-246es_ES
dc.subjecteyees_ES
dc.subjectadversse effectses_ES
dc.subjectmonoclonal antibodyes_ES
dc.subjectintravitreal therapyes_ES
dc.subjectPosterior segment diseasees_ES
dc.subjectophthalmic diseaseses_ES
dc.titleMonoclonal antibodies: A therapeutic option for the treatment of ophthalmic diseases of the eye posterior segmentes_ES
dc.typeartículo de revisiónes_ES

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