A facile method for the preparation of bishomopropargylic alcohols from acyl chlorides
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Authors
Vásquez Céspedes, Suhelen
Cabezas Pizarro, Jorge A.
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Abstract
Controlled dilithiation of propargyl bromide with two equivalents of n-butyllithium, in the presence of
TMEDA, produces the operational equivalent of the dianion 1,3-dilithiopropyne. The latter reacts
efficiently with acid chlorides to produce bishomopropargylic alcohols in a single step route and with
high regioselectivity and moderate yields.
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Keywords
QUÍMICA, 1,3-Dilithiopropyne, Propargyl bromide lithiation, Homopropargylation, Homopropargyl alcohols, Bishomopropargyl alcohols
Citation
https://www.sciencedirect.com/science/article/pii/S0040403914002007