The Natural Products Atlas 2.0: a database of microbially-derived natural products

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dc.creatorvan Santen, Jeffrey A.
dc.creatorPoynton, Ella F.
dc.creatorIskakova, Dasha
dc.creatorMcMann, Emily
dc.creatorAlsup, Tyler A.
dc.creatorClark, Trevor N.
dc.creatorFergusson, Claire H.
dc.creatorFewer, David P.
dc.creatorHughes, Alison H.
dc.creatorMcCadden, Caitlin A.
dc.creatorParra Villalobos, Jonathan
dc.creatorSoldatou, Sylvia
dc.creatorRudolf, Jeffrey D.
dc.creatorJanssen, Elisabeth M. L.
dc.creatorDuncan, Katherine R.
dc.creatorLinington, Roger G.
dc.date.accessioned2024-07-03T20:40:16Z
dc.date.available2024-07-03T20:40:16Z
dc.date.issued2021-10-28
dc.description.abstractWithin the natural products field there is an increasing emphasis on the study of compounds from microbial sources. This has been fuelled by interest in the central role that microorganisms play in mediating both interspecies interactions and host-microbe relationships. To support the study of natural products chemistry produced by microorganisms we released the Natural Products Atlas, a database of known microbial natural products structures, in 2019. This paper reports the release of a new version of the database which includes a full RESTful application programming interface (API), a new website framework, and an expanded database that includes 8128 new compounds, bringing the total to 32 552. In addition to these structural and content changes we have added full taxonomic descriptions for all microbial taxa and have added chemical ontology terms from both NP Classifier and ClassyFire. We have also performed manual curation to review all entries with incomplete configurational assignments and have integrated data from external resources, including CyanoMetDB. Finally, we have improved the user experience by updating the Overview dashboard and creating a dashboard for taxonomic origin. The database can be accessed via the new interactive website at https://www.npatlas.org.es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Farmaciaes_ES
dc.identifier.citationhttps://academic.oup.com/nar/article/50/D1/D1317/6413589es_ES
dc.identifier.doi10.1093/nar/gkab941
dc.identifier.issn1362-4962
dc.identifier.issn0305-1048
dc.identifier.urihttps://hdl.handle.net/10669/91686
dc.language.isoenges_ES
dc.rightsacceso abiertoes_ES
dc.sourceNucleic Acids Research, 50, D1317-D1323es_ES
dc.subjectnatural productses_ES
dc.subjectmicrobial sourceses_ES
dc.subjectNatural Products Atlases_ES
dc.titleThe Natural Products Atlas 2.0: a database of microbially-derived natural productses_ES
dc.typeartículo originales_ES

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