Physicochemical Characterization of a Liposomal Formulation Based on Glucosamine and Vitamin D, Commercialized as a Nutritional Supplement
Fecha
2018
Tipo
artículo original
Autores
Madrigal Redondo, German
Vargas Zúñiga, Rolando
Chavarría Rojas, Marianela
Sibaja Rodríguez, Santiago
Chaves Noguera, Sindy
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Resumen
In the last years, the transport and release mechanism of bioactive compounds has been studied.
The liposomes are multivesicular systems that enhance the absorption, stability, and transport of
these compounds. The glucosamine is an amino-monosaccharide, it has been associated with
many biological activities, but its bioavailability and oral stability are very low. For this reason, the
glucosamine formulation in liposomal systems is a good alternative.
In this paper, the physicochemical characterization of a liposomal formulation based on
glucosamine and vitamin D was realized, this formulation is commercialized as a diet supplement.
The determination of pH, degrees Brix, refraction index and specific gravity was realized to characterize the formulation. On the other hand, the structure, size (diameter) and membrane
thickness of the liposomes were measured by microscopic observation.
From the formulation analysis, it is possible to affirm that the liposomes are multivesicular
structures. Also, the external membrane thickness is higher than the membrane thickness of the
encapsulated liposomes, indicating the liposomes could be multilamellar structures. The
multilamellar and multivesicular structures are related to a high stability, resulting in a beneficial
aspect of the formulation. Additionally, the dimension and structure conformation are related with
an efficient encapsulation process of the active components, which are glucosamine and vitamin D.
Descripción
Palabras clave
Glucosamine, Multilamellar liposomes, Multivesicular liposomes, Nutritional product, Phosphatidylcholine, Vitamin D