dc.creator | González Hernández, Jerson | |
dc.creator | Ott, Colby Edward | |
dc.creator | Arcos Martínez, María Julia | |
dc.creator | Colina, Álvaro | |
dc.creator | Heras, Aránzazu | |
dc.creator | Alvarado Gámez, Ana Lorena | |
dc.creator | Urcuyo Solórzano, Roberto | |
dc.creator | Arroyo Mora, Luis E. | |
dc.date.accessioned | 2022-08-08T15:37:33Z | |
dc.date.available | 2022-08-08T15:37:33Z | |
dc.date.issued | 2021-12-31 | |
dc.identifier.citation | https://www.mdpi.com/1424-8220/22/1/295 | es_ES |
dc.identifier.issn | 1424-8220 | |
dc.identifier.uri | https://hdl.handle.net/10669/87135 | |
dc.description.abstract | The synthetic cathinones mephedrone (4-MMC) and 4-methylethcathinone (4-MEC) are
two designer drugs that represent the rise and fall effect of this drug category within the stimulants
market and are still available in several countries around the world. As a result, the qualitative
and quantitative determination of ‘legal highs’, and their mixtures, are of great interest. This work
explores for the first time the spectroelectrochemical response of these substances by coupling
cyclic voltammetry (CV) with Raman spectroscopy in a portable instrument. It was found that the
stimulants exhibit a voltammetric response on a gold screen-printed electrode while the surface is
simultaneously electro-activated to achieve a periodic surface-enhanced Raman spectroscopy (SERS)
substrate with high reproducibility. The proposed method enables a rapid and reliable determination
in which both substances can be selectively analyzed through the oxidation waves of the molecules
and the characteristic bands of the electrochemical SERS (EC-SERS) spectra. The feasibility and
applicability of the method were assessed in simulated seized drug samples and spiked synthetic
urine. This time-resolved spectroelectrochemical technique provides a cost-effective and user-friendly
tool for onsite screening of synthetic stimulants in matrices with low concentration analytes for
forensic applications. | es_ES |
dc.description.sponsorship | Universidad de Costa Rica//UCR/Costa Rica | es_ES |
dc.description.sponsorship | Ministerio de Innovación, Ciencia, Tecnología y Telecomunicaciones//MICITT/Costa Rica | es_ES |
dc.language.iso | eng | es_ES |
dc.source | Sensors; Vol. 22 Núm. 1: 2022 | es_ES |
dc.subject | Spectroelectrochemistry | es_ES |
dc.subject | Synthetic cathinones | es_ES |
dc.subject | Raman SERS | es_ES |
dc.subject | 4-MMC | es_ES |
dc.subject | 4-MEC | es_ES |
dc.title | Rapid Determination of the ‘Legal Highs’ 4-MMC and 4-MEC by Spectroelectrochemistry: Simultaneous Cyclic Voltammetry and In Situ Surface-Enhanced Raman Spectroscopy | es_ES |
dc.type | artículo original | es_ES |
dc.identifier.doi | 10.3390/s22010295 | |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Electroquímica y Energía Química (CELEQ) | es_ES |
dc.description.procedence | UCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Química | es_ES |