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dc.creatorRamírez Arguedas, Nils Antonio
dc.creatorGonzález Mora, Esteban
dc.creatorMorera Huertas, Jessica
dc.creatorCarazo Berrocal, Gustavo
dc.creatorFonseca González, Lidiette
dc.date.accessioned2020-04-28T19:58:02Z
dc.date.available2020-04-28T19:58:02Z
dc.date.issued2016
dc.identifier.citationhttps://www.wjpr.net/index.php/dashboard/abstract_id/5688es_ES
dc.identifier.issn2277-7105
dc.identifier.urihttps://hdl.handle.net/10669/80937
dc.description.abstractThe method was validated by ultraviolet spectrophotometry for the determination of levofloxacin 500 mg tablets using dissolution profiles to establish therapeutic equivalence. The parameters were satisfactory according to accuracy and precision in a linear range between 2,0 μg/mL and 8.0μg/mL. Both, the relative error and relative standard deviation were less than 2%, the recovery was on average of 98,5%, the quantification limit (QL) obtained was 0,47 μg/mL. The effect of filters Varian ® Full FlowTM of 70 microns used in the dissolution equipment autosampler Varian ® 7010 and the effect of light were evaluated. For the effect of the filter, three concentrations levels were evaluated (3, 5, 7 μg/mL); no change in the recovery were observed applying a T-test (both sides, 95% limit of confidence). The effect of light was explored exposing levofloxacin standard’s to natural and artificial light for 0, 6, 24, 48, 62 and 86 hours. We find that after 24 hours the response have significance’s changes. With a both-sides, 95 % limit confidence ANOVA, the homocedasticity (Leven’s test) and normality test (Shapiro-Wilk) were checked. In conclude the developed method can be used to determine levofloxacine in tablets for profile dissolution, and the filter used does not affect, but light effect is important, and samples must not be handle for more than 24 hours.es_ES
dc.language.isoen_USes_ES
dc.sourceWorld Journal of Pharmaceutical Research, vol.5(8), pp.1482-1492es_ES
dc.subjectLevofloxacines_ES
dc.subjectValidationes_ES
dc.subjectFilter effectes_ES
dc.subjectPhotosensitivityes_ES
dc.titleEvaluation of the critical points in the validation of 500 mg levofloxacin tablets for dissolution profilees_ES
dc.typeartículo científicoes_ES
dc.identifier.doi10.20959/wjpr20168-6821
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones Farmacéuticas (INIFAR)es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Farmaciaes_ES


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