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Genetic polymorphism of CYP1A2 increases the risk of myocardial infarction
(2004)
There is growing evidence that DNA damage caused by mutagens found in tobacco smoke may contribute to the development of coronary heart disease (CHD). In order to bind to DNA many mutagens require metabolic activation by ...
Does genetic variation in the Δ6-desaturase promoter modify the association between α-linolenic acid and the prevalence of metabolic syndrome?
(2009)
Background: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with protection against components of the metabolic syndrome, but the role of α-linolenic acid (ALA), the metabolic precursor of EPA and ...
The relation between trans fatty acid levels and increased risk of myocardial infarction does not hold at lower levels of trans fatty acids in the costa rican food supply
(2006)
Data on the effects of recent industrial modifications that reduced the trans fatty acid (TFA) content in food supplies are scarce. In this study, incident cases (n = 1797) of a first nonfatal myocardial infarction (MI) ...
Transmission disequilibrium test (TDT) for case–control studies
(2004)
Genetic association, case–control studies are becoming a major instrument in the attempt to identify disease susceptibility markers of complex diseases. However, a major drawback of population-based studies of genetic ...
Coffee, CYP1A2 Genotype, and Risk of Myocardial Infarction
(2006)
ontext The association between coffee intake and risk of myocardial infarction (MI) remains controversial. Coffee is a major source of caffeine, which is metabolized by the polymorphic cytochrome P450 1A2 (CYP1A2) enzyme. ...
Dietary patterns and risk of nonfatal acute myocardial infarction in Costa Rican adults
(2006)
Cardiovascular disease (CVD) has become an important public health problem in transition countries in Latin America (Medina and Kaempffer, 2000; Cubillos-Garzón et al., 2004; Ventura and Mehra, 2004; World HealthOrganization, ...
Adipose tissue arachidonic acid and the metabolic syndrome in Costa Rican adults
(2007)
Arachidonic acid, a precursor to a series of inflammatory mediators, may contribute to the development of insulin resistance. We examined the association between adipose tissue arachidonic acid and the metabolic syndrome ...
α-Linolenic acid, Δ6-desaturase gene polymorphism, and the risk of nonfatal myocardial infarction
(2007)
Background:Δ6-Desaturase (FADS2) is the rate-limiting step in the polyunsaturated fatty acid (PUFA) biosynthetic pathway.
Objective: The aim was to test whether the common deletion [T/-] in the promoter of FADS2 affects ...
Decreased Consumption of Dried Mature Beans Is Positively Associated with Urbanization and Nonfatal Acute Myocardial Infarction
(2005)
Legumes may protect against myocardial infarction (MI). The objective of this study was to determine whether consumption of dried mature beans (referred to as beans), the main legume in Latin America, is associated with ...
Adipose tissue biomarkers of fatty acid intake
(2002)
The use of biomarkers to assess dietary intake has increased dramatically in the past few years (1-7). Biomarkers may provide a more accurate and objective measure of long-term intake than dietary questionnaires provide ...