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Novel catalytically-inactive PII metalloproteinases from a viperid snake venom with substitutions in the canonical zinc-binding motif
(2016-10-12)
Snake venom metalloproteinases (SVMPs) play key biological roles in prey immobilization
and digestion. The majority of these activities depend on the hydrolysis of relevant protein substrates
in the tissues. Hereby, we ...
Molecular Recognition of Surface Trans-Sialidases in Extracellular Vesicles of the Parasite Trypanosoma cruzi Using Atomic Force Microscopy (AFM)
(2022-06-28)
Trans-sialidases (TS) are important constitutive macromolecules of the secretome present on the surface of Trypanosoma cruzi (T. cruzi) that play a central role as a virulence factor in Chagas disease. These enzymes have ...
Prevalence of vitamin D deficiency in Costa Rican children
Prevalencia de deficiencia de vitamina D en niños de Costa Rica
(2021-04-12)
Objective: To determine the prevalence of vitamin D deficiency in children in the South- Central Region of Costa Rica.
Methods: A cross-sectional study was performed with Costa Rican children aged 1-7
years from the ...
High-throughput immuno-profiling of mamba (Dendroaspis) venom toxin epitopes using high-density peptide microarrays
(2016-11-08)
Snakebite envenoming is a serious condition requiring medical attention and administration of
antivenom. Current antivenoms are antibody preparations obtained from the plasma of animals
immunised with whole venom(s) and ...
Primer aislamiento e identificación molecular de Naegleria fowleri en Costa Rica
(2015-01)
La meningoencefalitis amebiana primaria, causada por Naegleria fowleri, es un cuadro agudo y fulminante. Esta es una ameba de vida libre (AVL) que presenta amplia distribución a nivel mundial. Presenta una moratildad alta ...