Listar Microbiología por título
Mostrando ítems 551-570 de 1169
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Hemorrhage Caused by Snake Venom Metalloproteinases: A Journey of Discovery and Understanding
(2016-03-26)The historical development of discoveries and conceptual frames for understanding the hemorrhagic activity induced by viperid snake venoms and by hemorrhagic metalloproteinases (SVMPs) present in these venoms is reviewed. ... -
Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage
(2005-06-15)Zinc-dependent metalloproteinases are responsible for the hemorrhagic activity characteristic of viperid snake venoms. Snake venom metalloproteinases (SVMPs) are classified in various groups (P-I–IV), according to their ... -
Hemostatic effects induced by Thalassophryne nattereri fish venom: a model of endothelium-mediated blood flow impairment.
(2002-08)Accidents by Thalassophryne nattereri fish venom are characterised by severe local symptoms and signs including pain of fast onset, oedema and necrosis with impaired muscle regeneration. These effects have been related to ... -
Heterogeneidad clonal en epimastigotos de una cepa centroamericana de Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae)
(2002)El fenómeno de heterogeneidad clonal fue evaluado en una cepa centroamericana de Trypanosoma cruzi (San Salvador) en un sistema de cultivo en macrófagos. Cuatro clones denominados Clon 9, Clon 10, Clon 11 y Clon 12 fueron ... -
Heterologous hyperimmune polyclonal antibodies against SARS-COV-2: A broad coverage, affordable, and scalable potential immunotherapy for Covid-19
(2021-09)The emergence and dissemination of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the resulting COVID-19 pandemic triggered a global public health crisis. Although several SARS-CoV-2 vaccines have ... -
High Efficacy of Therapeutic Equine Hyperimmune Antibodies Against SARS-CoV-2 Variants of Concern
(2021)SARS-CoV-2 variants of concern show reduced neutralization by vaccine-induced and therapeutic monoclonal antibodies; therefore, treatment alternatives are needed. We tested therapeutic equine polyclonal antibodies (pAbs) ... -
High Prevalence of Multidrug-Resistant Community-Acquired Methicillin-Resistant Staphylococcus aureus at the Largest Veterinary Teaching Hospital in Costa Rica
(2017-08-17)Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogen associated with severe infections in companion animals present in the community, and it is diagnosed in animals admitted to veterinary hospitals. However, ... -
High quality 3C de novo assembly and annotation of a multidrug resistant ST-111 Pseudomonas aeruginosa genome: Benchmark of hybrid and non-hybrid assemblers
(2020)Genotyping methods and genome sequencing are indispensable to reveal genomic structure of bacterial species displaying high level of genome plasticity. However, reconstruction of genome or assembly is not straightforward ... -
High resolution analysis of snake venom metalloproteinase (SVMP) peptide bond cleavage specificity using proteome based peptide libraries and mass spectrometry
(2011-04-01)Both serine and metalloproteinases have been shown to play the role of toxins in the venoms of many snakes. Determination of the natural protein substrates of these toxins is an important feature in the toxinological ... -
High-density peptide microarray exploration of the antibody response in a rabbit immunized with a neurotoxic venom fraction
(2017-11)Polyvalent snakebite antivenoms derive their therapeutic success from the ability of their antibodies to neutralize venom toxins across multiple snake species. This ability results from a production process involving ... -
High-Resolution Crystal Structure of the Snake Venom Metalloproteinase BaP1 Complexed with a Peptidomimetic: Insight into Inhibitor Binding
(2009-07-07)BaP1, a zinc-dependent endopeptidase belonging to the P-I class of snake venom metalloproteinases, exerts multiple tissue-damaging activities, leading to hemorrhage, myonecrosis, dermonecrosis, blistering, and edema. ... -
High-throughput immuno-profiling of mamba (Dendroaspis) venom toxin epitopes using high-density peptide microarrays
(2016-11-08)Snakebite envenoming is a serious condition requiring medical attention and administration of antivenom. Current antivenoms are antibody preparations obtained from the plasma of animals immunised with whole venom(s) and ... -
Highlights in Suicidal Ideation and Non-suicidal self-injury in Costa Rica children and Adolescents
(2022)Suicidal ideation and deliberate self-harm prevalence has markedly increased among youngsters over the past two decades. The objective of the work was to determine the prevalence and factors associated with deliberate ... -
Highly individual patterns of virus‑immune IgG effector responses in humans
(2016-05-18)t IgG responses are fundamental to adaptive immunity and document immunological memory of previous pathogen encounter. While specific antigen recognition is mediated by the variable F(ab′)2 domain of IgG, various effector ... -
Hiperfibrinólisis: mecanismos fisiopatológicos, métodos diagnósticos y tratamiento
(2021-07)En las últimas décadas, con el incremento de los procedimientos médicos mayores como cirugías cardíacas, trasplantes de órgano sólido, y de los accidentes en carretera, la importancia de la hiperfibrinólisis se ha hecho ... -
Histopathological and biochemical alterations induced by intramuscular injection of Bothrops asper (terciopelo) venom in mice
(1989)The local and systemic pathological changes induced by an i.m. injection of 100 micrograms of Bothrops asper venom in mice were studied histologically and by following the changes in serum levels of enzymes, proteins, ATP ... -
La Homocisteína como nuevo factor de riesgo cardiovascular
(2004)En la actualidad se tiene un amplio conocimiento de los factores de riesgo asociados con esta enfermedad. Sin embargo, las causas que inducen el inicio del proceso patológico aún son motivo de discusión. Los factores de ... -
Homogenates of skeletal muscle injected with snake venom inhibit myogenic differentiation in cell culture
(2013-02)Introduction: Viperid snakebite envenomings are characterized by muscle necrosis and a deficient regenerative response. Methods: Homogenates from gastrocnemius muscles of mice injected with the venom of the snake Bothrops ... -
Horse IgG isotypes and cross-neutralization of two snake antivenoms produced in Brazil and Costa Rica
(2000-05)Horse IgG isotypes and cross-neutralization of two snake antivenoms produced in Brazil and Costa Rica. Toxicon 000–000. This work compared the specificity, ELISA titers and IgG subclass content of the polyvalent antivenom ...