Listar Microbiología por autor "9fd806b0-aac6-46b7-a1c1-46496a60d8af"
Mostrando ítems 1-17 de 17
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A Clostridium difficile Lineage Endemic to Costa Rican Hospitals Is Multidrug Resistant by Acquisition of Chromosomal Mutations and Novel Mobile Genetic Elements
Ramírez Vargas, Gabriel; Quesada Gómez, Carlos; Acuña Amador, Luis Alberto; López Ureña, Diana; Murillo Corrales, Tatiana; Gamboa Coronado, María del Mar; Chaves Olarte, Esteban; Thomson, Nicholas R.; Rodríguez Cavallini, Evelyn; Rodríguez Sánchez, César (2017-01)The antimicrobial resistance (AMR) rates and levels recorded for Clostridium difficile are on the rise. This study reports the nature, levels, diversity, and genomic context of the antimicrobial resistance of human C. ... -
A MLST Clade 2 Clostridium difficile strain with a variant TcdB induces severe inflammatory and oxidative response associated with mucosal disruption
Leite Costa, Cecília; López Ureña, Diana; de Oliveira Assis, Thiago; Ribeiro, Ronaldo de Albuquerque; Silveira Silva, Rodrigo Otavio; Rupnik, Maja; Wilcox, Mark H.; Fiorini de Carvalho, Alex; Oliveira do Carmo, Anderson; Abalen Martins Dias, Adriana; Barreto Mano de Carvalho, Cibele; Chaves Olarte, Esteban; Rodríguez Sánchez, César; Quesada Gómez, Carlos; de Castro Brito, Gerly Anne (2016-08)The epidemiology of Clostridium difficile infections is highly dynamic as new strains continue to emerge worldwide. Here we present a detailed analysis of a new C. difficile strain (ICC-45) recovered from a cancer patient ... -
Agentes bacterianos asociados al cáncer colorrectal y su potencial uso como biomarcadores
Rodríguez González, María José (2021)Existe una asociación epidemiológica del CCR con los tres agentes bacterianos tratados en esta revisión. Estos se han encontrado en tejido epitelial tumoral y en menor medida en tejido colónico adyacente sano, así como ... -
Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities
Quesada Gómez, Carlos; López Ureña, Diana; Chumbler, Nicole; Kroh, Heather K.; Castro Peña, Carolina; Rodríguez Sánchez, César; Orozco Aguilar, Josué; González Camacho, Sara María; Rucavado Romero, Alexandra; Guzmán Verri, Caterina; Lawley, Trevor D.; Lacy, D. Borden; Chaves Olarte, Esteban (2016-03)Clostridium difficile strains within the hypervirulent clade 2 are responsible for nosocomial outbreaks worldwide. The increased pathogenic potential of these strains has been attributed to several factors but is still ... -
Emergence of an Outbreak-Associated Clostridium difficile Variant with Increased Virulence
Quesada Gómez, Carlos; López Ureña, Diana; Chaves Olarte, Esteban; Acuña Amador, Luis Alberto; Villalobos Zúñiga, Manuel Antonio; Du, Tim; Freire, Rosemayre; Guzmán Verri, Caterina; Gamboa Coronado, María del Mar; Lawley, Trevor D.; Moreno Robles, Edgardo; Mulvey, Michael R.; de Castro Brito, Gerly Anne; Rodríguez Cavallini, Evelyn; Rodríguez Sánchez, César (2015-04)The prevalence of Clostridium difficile infections has increased due to the emergence of epidemic variants from diverse genetic lineages. Here we describe the emergence of a novel variant during an outbreak in a Costa Rican ... -
Emergence of Clostridium difficile NAP1 in Latin America
Quesada Gómez, Carlos; Rodríguez Sánchez, César; Gamboa Coronado, María del Mar; Rodríguez Cavallini, Evelyn; Du, Tim; Mulvey, Michael R.; Villalobos Zúñiga, Manuel Antonio; Boza Cordero, Ricardo (2010-02)The NAP1 and NAP2 strains of Clostridium difficile have been linked to nosocomial outbreaks of antibiotic-associated diarrhea (AAD) and pseudomembranous colitis in North American and European countries (4, 5). We found ... -
Isolation of a Toxigenic and Clinical Genotype of Clostridium difficile in Retail Meats in Costa Rica
Quesada Gómez, Carlos; Mulvey, Michael R.; Vargas Dengo, Pablo Antonio; Gamboa Coronado, María del Mar; Rodríguez Sánchez, César; Rodríguez Cavallini, Evelyn (2013-02)We isolated a regional toxigenic genotype of Clostridium difficile, previously found in human infection in 4 of 200 (2%) samples of retail meats for human consumption: 1 of 67 samples of beef, 2 of 66 of pork, and 1 of 67 ... -
Molecular epidemiology and antimicrobial resistance of Clostridium difficile in a national geriatric hospital in Costa Rica
Jiménez Solís, Andrea; Araya, R.; Paniagua Hidalgo, Diana; Camacho Mora, Zianne; Du, Tim; Golding, Geroge R.; Leandro Astorga, Gustavo; Rodríguez Sánchez, César; Quesada Gómez, Carlos (2018-08)Background: the epidemiology of Clostridium difficile infections (CDI) is changing rapidly worldwide; knowledge on the genotypes of C. difficile circulating in specialized geriatric hospitals and their resistance to ... -
Molecular epidemiology of Clostridium difficile infection in a Brazilian cancer hospital
Leite Costa, Cecília; Barreto Mano de Carvalho, Cibele; Holanda González, Rafael; Cavalcante Gifoni, Markus Andret; Ribeiro, Ronaldo de Albuquerque; Quesada Gómez, Carlos; de Castro Brito, Gerly Anne (2017)Clostridium difficile is a Gram-positive spore forming anaerobic bacterium and the main cause of healthcare-associated diarrhea. This study aimed to perform the phenotypic characterization and molecular typing of Clostridium ... -
Novel Clade C-I Clostridium difficile strains escape diagnostic tests, differ in pathogenicity potential and carry toxins on extrachromosomal elements
Ramírez Vargas, Gabriel; López Ureña, Diana; Badilla Lobo, Adriana; Orozco Aguilar, Josué; Murillo Corrales, Tatiana; Rojas, Priscilla; Riedel, Thomas; Overmann, Jörg; González, Gabriel; Chaves Olarte, Esteban; Quesada Gómez, Carlos; Rodríguez Sánchez, César (2018)The population structure of Clostridium difficile currently comprises eight major genomic clades. For the highly divergent C-I clade, only two toxigenic strains have been reported, which lack the tcdA and tcdC genes and ... -
Phenotypic and Genotypic Characterization of Multidrug-Resistant Bacteroides, Parabacteroides spp., and Pseudoflavonifractor from a Costa Rican Hospital
Molina Mora, José Arturo; Barrantes, Gloriana; Quesada Gómez, Carlos; Rodríguez Sánchez, César; Rodríguez Cavallini, Evelyn (2014-09)Multidrug resistance in Bacteroides spp. and related genera is uncommon and has not been described in Latin America until now. We studied phenotypically and genotypically the multidrug resistance of 10 clinical strains of ... -
Phenotypic identification of over 1000 isolates of anaerobic bacteria recovered between 1999 and 2008 in a major Costa Rican hospital
Rodríguez Cavallini, Evelyn; Vargas Dengo, Pablo Antonio; Rodríguez Sánchez, César; Gamboa Coronado, María del Mar; Quesada Gómez, Carlos (2011-07)Because of limitations in infrastructure, the aetiology of infections caused by anaerobic bacteria is seldom determined in clinical laboratories of developing countries. This study reports on the identification of 1010 ... -
Predominance and high antibiotic resistance of the emerging Clostridium difficile genotypes NAPCR1 and NAP9 in a Costa Rican hospital over a 2-year period without outbreaks
López Ureña, Diana; Quesada Gómez, Carlos; Montoya Ramírez, Mónica; Gamboa Coronado, María del Mar; Somogyi Pérez, Teresa; Rodríguez Sánchez, César; Rodríguez Cavallini, Evelyn (2016-05)Clostridium difficile is the major causative agent of nosocomial antibiotic-associated diarrhea. In a 2009 outbreak of C. difficileassociated diarrhea that was recorded in a major Costa Rican hospital, the hypervirulent ... -
Proteogenomic analysis of the Clostridium difficile exoproteome reveals a correlation between phylogenetic distribution and virulence potential
Quesada Gómez, Carlos; Murillo Corrales, Tatiana; Arce, Grettel; Badilla Lobo, Adriana; Castro Peña, Carolina; Molina Mora, José Arturo; López Ureña, Diana; González Camacho, Sara María; Lomonte, Bruno; Chacón Díaz, Carlos; Rodríguez Sánchez, César; Chaves Olarte, Esteban (2020)C. difficile induces antibiotic-associated diarrhea due to the action of two secreted toxins, TcdA and TcdB. A considerable range of virulence among C. difficile strains has been widely reported. During a hospital outbreak, ... -
Scarce detection of mobile erm genes associated with tetQ in Bacteroides and Parabacteroides from Costa Rica
Quesada Gómez, Carlos; Rodríguez Cavallini, Evelyn; Rodríguez Sánchez, César (2013-06)The frequency of finding of clindamycin-resistant anaerobic bacteria in clinical samples has doubled from 2008 to 2010 in Costa Rica. To determine whether this increase is due to dissemination of erm genes aided by tetQ ... -
Toxin B Variants from Clostridium difficile Strains VPI 10463 and NAP1/027 Share Similar Substrate Profile and Cellular Intoxication Kinetics but Use Different Host Cell Entry Factors
López Ureña, Diana; Orozco Aguilar, Josué; Chaves Madrigal, Yendry Pamela; Ramírez Mata, Andrea; Villalobos Jimenez, Amanda; Ost, Stefan; Quesada Gómez, Carlos; Rodríguez Sánchez, César; Papatheodorou, Panagiotis; Chaves Olarte, Esteban (2019)Clostridium difficile induces antibiotic-associated diarrhea due to the release of toxin A (TcdA) and toxin B (TcdB), the latter being its main virulence factor. The epidemic strain NAP1/027 has an increased virulence ... -
Virulent Brucella nosferati infecting Desmodus rotundus has emerging potential due to the broad foraging range of its bat host for humans and wild and domestic animals
Hernández Mora, Gabriela; Chacón Díaz, Carlos; Moreira Soto, Andrés; Barrantes Granados, Osvaldo; Suárez Esquivel, Marcela; Víquez Ruiz, Eunice; Barquero Calvo, Elías; Ruiz Villalobos, Nazareth; Hidalgo Montealegre, Daniela; González Barrientos, Rocío; Demeter, Elena A.; Estrella Morales, Josimar; Zúñiga Pereira, Ana Mariel; Quesada Gómez, Carlos; Chaves Olarte, Esteban; Lomonte, Bruno; Guzmán Verri, Caterina; Drexler, Jan Felix; Moreno Robles, Edgardo (2023)Desmodus rotundus, vampire bats, transmit dangerous infections, and brucellosis is a hazardous zoonotic disease, two adversities that coexist in the subtropical and tropical areas of the American continent. Here, we report ...