Molecular epidemiology and antimicrobial resistance of Clostridium difficile in a national geriatric hospital in Costa Rica
artículo original
Fecha
2018-08Autor
Jiménez Solís, Andrea
Araya, R.
Paniagua Hidalgo, Diana
Camacho Mora, Zianne
Du, Tim
Golding, Geroge R.
Leandro Astorga, Gustavo
Rodríguez Sánchez, César
Quesada Gómez, Carlos
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Background: the epidemiology of Clostridium difficile infections (CDI) is changing rapidly worldwide; knowledge on the genotypes of C. difficile circulating in specialized geriatric hospitals and their resistance to antibiotics is scarce or non-existent.
Methods: prospective study of the molecular epidemiology of CDI, conducted in a national geriatric hospital in Costa Rica for a period of 11 months.
Results: the study patients exhibited a diverse range of comorbidities, but none were associated with CDI. Polyclonality, including three new ribotypes, and a high level of resistance to antibiotics were determined by analysing the 32 isolates obtained in these cases. Despite the diversity in strains observed, the most frequent types were NAP6/RT002 and NAP2/RT001. NAP9/RT017 was associated with community acquisition. Nineteen types of antimicrobials were used before the onset of diarrhoea in the patients; no particular genotype was associated with the onset of infection or severity.
Conclusion: based on the abundance of strain types observed and their resistance to antibiotics in this geriatric hospital, these results contribute to a better overall understanding of the epidemiology of CDI worldwide, and to surveillance programmes targeting geriatric populations.
External link to the item
10.1016/j.jhin.2018.03.027Colecciones
- Microbiología [1171]