Revista Clínica Escuela de Medicina UCR-HSJD, Volumen 2, Número 5

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  • Ítem
    PÉNFIGO VULGAR
    (2011-07-01 00:00:00) Rodríguez Sánchez, Orlando
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    REVISIÓN SOBRE LA RELACIÓN DEL GENOTIPO PARA APOE4 Y EL DESARROLLO DE DEMENCIA TIPO ALZHEIMER
    (2011-07-01 00:00:00) Román Garita, Nórbel; Boza Calvo, Carolina
    Introduction: Alzheimer’s disease is the mostcommon cause of dementia. Although there is anearly manifestation of 3 dominant autosomalgenes, they only explain between 1-2% of allcases. Efforts are made to establish the genetic risk for early diagnosis of the disease. Method:There are many scientific studies related to pre-vention, diagnosis and treatment of Alzheimer-type dementia. This review focuses on the pres-ence of the ApoE gene and its relationship to thedevelopment and progression of the disease.Conclusions: Alzheimer type dementia has mul-tifactorial origin; however, for late-onset casesthe presence of the ApoE4 genotype is an im-portant biomarker of risk factor. 
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    ENFERMEDAD DE BUERGER
    (2011-07-01 00:00:00) Cascante Quirós, Ana Yanci; Mesén Ramírez, Jorge; Jiménez Juárez, Róger
    Thromboangiitis obliterans also known asBuerger’s Disease is a segmental, inflammatory,occlusive, non-atherosclerotic disease that involves small and medium caliber arteries, veinsand nerves; affects mainly young males withtobacco abuse history.The clinical presentation is caused for the occlusion and stenosis of the distal vasculature in upper and lower limbs. The initial ischemicsymptoms are intermittent claudication in theaffected extremities. In the natural history of thedisease, patients can present severe ischemia ofthe limbs (rest pain, ulcers, and digital gangrene).Arteriographic studies show a pattern of abruptocclusion of the distal vasculature, with areas ofnormal vessels between the affected segments,with intense tortuosity in the recanalized segments described in a “corkscrew shape”. Thehistology varies according to the phase of thedisease but usually and occlusive intraluminalthrombus with lymphocytes, giant cells, inflammation of the media and the adventitia with aninternal elastic lamina unaffected. The key oftreatment is to eliminate the smoking but alsosome pharmacologic and surgical approacheshave been established as well as new therapiesunder trials. 
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    PLICATURA GÁSTRICA
    (2011-07-01 00:00:00) Fallas González, Jorge; Barrantes Monge, Ricardo; Ugalde Ovares, Carlos; González Fernández, Jessica
    In bariatric surgery several different techniqueshave been developed, with different mechanismsof action and indications; recently gastricplication has been implemented as an alternative for the treatment of morbid obesity. It has shownresults of excess weight loss compared to othertechniques such as gastric sleeve. It also offersdistinct advantages over other proceduresbecause of the non-resective nature of plication. Being a new technique, we describe it andpresent the most important results obtained sofar.   
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    ACIDOSIS LÁCTICA TIPO B1 SECUNDARIA A LINFOMA DE BURKITT.
    (2011-07-01 00:00:00) Jiménez Brenes, Natalia; Rojas Vega, Jason; Barguil Meza, Ibrahim
    Lactic acidosis is a rare complication of malignant neoplasms first described in patients with acute leukemia in 1963. Since then, there hasbeen seen more often, particularly in hematological malignancies and rarely in solid tumors. Wereport the case of a 53 years old male with lactacidosis B1 and gastric Burkitt lymphoma whowas admitted to the hospital with constitutionalsymptoms, weight loss, diarrhea and melena.Arterial blood gases revealed a metabolic acidosis with increased anion gap (pH:7,278; HCO3-:9,1mmol/l; AG: 20) and elevated lactate (15,5mmol/l). Other causes of lactacidosis, as circula-tory failure, sepsis and shock were ruledout. Common causes of type B lactic acidosiswere also excluded, such as infections, diabetesmellitus, renal failure, liver failure, thiaminedeficiency, drugs and toxins.