Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments
artículo original
Fecha
2017Autor
Mike, Laura A.
Tripathi, Ashootosh
Blankenship, Connor M.
Saluk, Alyssa
Schultz, Pamela J.
Tamayo Castillo, Giselle
Sherman, David H.
Mobley, Harry L. T.
Metadatos
Mostrar el registro completo del ítemResumen
High-throughput screening and activity-guided purification identified nicoyamycin A, a natural product comprised of an uncommon 3-methyl-1,4-dioxane ring incorporated into a desferrioxamine-like backbone via a spiroaminal linkage. Nicoyamycin A potently inhibits uropathogenic Escherichia coli growth in low iron medium, a promising step toward developing novel antibiotics to treat recalcitrant bacterial infections.
External link to the item
10.1039/c7cc07732gColecciones
- Biología [1644]