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dc.creatorAlpízar Alpízar, Warner
dc.creatorDidrik Laerum, Ole
dc.creatorChristensen, Ib J.
dc.creatorOvrebo, Kjell
dc.creatorSkarstein, Arne
dc.creatorHøyer Hansen, Gunilla
dc.creatorPloug, Michael
dc.creatorIllemann, Martin
dc.date.accessioned2017-12-21T20:17:27Z
dc.date.available2017-12-21T20:17:27Z
dc.date.issued2016
dc.identifier.citationhttp://journals.sagepub.com/doi/10.1369/0022155416656173es_ES
dc.identifier.issn0022-1554
dc.identifier.issn1551-5044
dc.identifier.urihttp://hdl.handle.net/10669/73731
dc.description.abstractThe tissue inhibitor of metalloproteinase-1 (TIMP-1) inhibits the extracellular matrix–degrading activity of several matrix metalloproteinases, thereby regulating cancer cell invasion and metastasis. Studies describing the expression pattern and cellular localization of TIMP-1 in gastric cancer are, however, highly discordant. We addressed these inconsistencies by performing immunohistochemistry and in situ hybridization analyses in a set of 49 gastric cancer lesions to reexamine the TIMP-1 localization. In addition, we correlated these findings to clinicopathological parameters. We show that strong expression of TIMP-1 protein and mRNA was observed in a subpopulation of stromal fibroblast-like cells at the periphery of the cancer lesions. In a few cases, a small fraction of cancer cells showed weak expression of TIMP-1 protein and mRNA. The stromal TIMP-1-expressing cells were mainly tumor-associated myofibroblasts. In the normal-appearing mucosa, scattered TIMP-1 protein was only found in chromogranin A positive cells. TIMP-1-positive myofibroblasts at the invasive front of the tumors were more frequently seen in intestinal than in diffuse histological subtype cases (p=0.009). A significant trend to a higher number of cases showing TIMP-1 staining in myofibroblasts with increasing tumor, node, metastasis (TNM) stage was also revealed (p=0.041). In conclusion, tumor-associated myofibroblasts are the main source of increased TIMP-1 expression in gastric cancer.es_ES
dc.description.sponsorshipDanish Cancer Society/[R2-A261-09-S2]//Europaes_ES
dc.description.sponsorshipEuropean Community’s Seventh Framework Program/[201279]/FP7/Europaes_ES
dc.description.sponsorshipAxel Muusfeldts Fond/[]//Europaes_ES
dc.description.sponsorshipKrista og Viggo Petersens Fond/[]/KV/Europaes_ES
dc.language.isoen_USes_ES
dc.sourceJournal of Histochemistry & Cytochemistry; Volumen 64, Número 8, 2016es_ES
dc.subjectGastric canceres_ES
dc.subjectImmunohistochemistryes_ES
dc.subjectIn situ hybridizationes_ES
dc.subjectInvasiones_ES
dc.subjectMyofibroblastses_ES
dc.subjectNeuroendocrine cellses_ES
dc.subjectTIMP-1es_ES
dc.titleTissue Inhibitor of Metalloproteinase-1 Is Confined to Tumor-Associated Myofibroblasts and Is Increased With Progression in Gastric Adenocarcinomaes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1369/0022155416656173
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Estructuras Microscópicas (CIEMIC)es_ES
dc.identifier.pmid27370797


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