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Quantitative genetic analysis of anxiety trait in bipolar disorder
(2017)
Background:Bipolar disorder type I (BPI) affects approximately 1% of the world population. Although geneticinfluences on bipolar disorder are well established, identification of genes that predispose to the illness has ...
Rediscovering the value of families for psychiatric genetics research
(2018-06-28)
As it is likely that both common and rare genetic variation are important for complex disease risk, studies that examine the full range of the allelic frequency distribution should be utilized to dissect the genetic ...
Chapter 6: Founder variations in isolated populations
(2020)
Isolated populations, also called population isolates and genetic isolates, present several characteristic features that make them useful in the study of the genetic basis of both Mendelian and complex disorders. The ...
Sobre el genoma humano, la medicina personalizada y el sistema de seguridad social
(2016)
La promesa del proyecto del genoma humano (PGH) fue que iba a transformar radicalmente la práctica médica. Cambiaría el paradigma de “diagnóstico y tratamiento” por el de “predicción de riesgo y prevención”. Hace más de ...
IVF in Costa Rica
(2017)
For 16 years, Costa Rica was the only country in the world that banned IVF, after it had been successfully conducted from 1995 to 2000. It also has been the only country that banned IVF based on the argument that it protects ...
Neuropsychological Test Performance in Cognitively Normal Spanish-speaking Nonagenarians with Little Education
(2016-06)
To find associations of age, sex, and education with neuropsychological test performance in cognitively normal Spanish-speaking Costa Rican nonagenarians with little education; to provide norms; and to compare their ...
A genome‐wide quantitative trait locus (QTL) linkage scan of NEO personality factors in Latino families segregating bipolar disorder
(2017)
Personality traits have been suggested as potential endophenotypes for Bipolar Disorder (BP), as they can be quantitatively measured and show correlations with BP. The present study utilized data from 2,745 individuals ...
Identification of circadian gene variants in bipolar disorder in Latino populations
(2015)
Background:
Variations in circadian genes can impact biological rhythms. Given the rhythm disturbances that characterize bipolar disorder (BD), genes encoding components of molecular clocks are good candidate genes for ...
Substance use disorder comorbidity with schizophrenia in families of Mexican and Central American Ancestry
(Schizophrenia Research 120 (2010) 87–94, 2010)
Objectives:The aims of this study were to estimate the frequency and course of substances use disorders in Latino patients with schizophrenia and to ascertain risk factors associated with substance use disorders in this ...
Genome-wide QTL analysis for anxiety trait in bipolar disorder type I
(2017)
Background Genetic studies have been consistent that bipolar disorder type I (BPI) runs in families and that this familial aggregation is strongly influenced by genes. In a preliminary study, we proved that anxiety trait ...