Listar Biología por autor "14974b96-b549-4f0e-9d8f-5f98a6bed749"
Mostrando ítems 1-9 de 9
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Evaluation of pharmacological therapies used in Costa Rica in patients with metastatic gastric cancer: a retrospective study
Cordero García, Eugenia; Ramos Esquivel, Allan Eduardo; Alpízar Alpízar, Warner (2019-01-18)Background: Gastric cancer is one of the leading causes of cancer death worldwide. Surgery is regarded as the best curative treatment option for gastric cancer; however, a high proportion of cases are diagnosed at advanced ... -
Evaluation of the expression of the oncogen C-ERBB-2/HER2 in advanced gastric cancer cases from Costa Rica
Cordero García, Eugenia; Baéz Astúa, Andrés; Roa Martínez, Yolanda; Ramírez Mayorga, Vanessa; Alpízar Alpízar, Warner (2019-09-19)Justification: The prevalence of gastric cancer (GC) with increased expression of the HER2 oncoprotein shows important variations worldwide. Incidence and mortality rates of GC in Costa Rica are among the highest in Latin ... -
Gastric cancer in the era of immune checkpoint blockade
Figueroa Protti, Lucía; Soto Molinari, Rebeca; Calderón Osorno, Melany; Mora Rodríguez, Javier Francisco; Alpízar Alpízar, Warner (2019-09-24)Gastric cancer (GC) is one of the most important malignancies worldwide because of its high incidence and mortality. The very low survival rates are mainly related to late diagnosis and limited treatment options. GC is the ... -
Helicobacter pylori Colonization Drives Urokinase Receptor (uPAR) Expression in Murine Gastric Epithelium During Early Pathogenesis
Alpízar Alpízar, Warner; Skindersoe, Mette Elena; Rasmussen, Lone; Kriegbaum, Mette Camila; Christensen, Ib J.; Lund, Ida Katrine; Illemann, Martin; Laerum, Ole Didrik; Krogfelt, Karen Angeliki; Andersen, Leif Percival; Ploug, Michael (2020)(1) Background: Persistent Helicobacter pylori infection is the most important risk factor for gastric cancer. The urokinase receptor (uPAR) is upregulated in lesions harboring cancer invasion and inflammation. Circumstantial ... -
Inflammation and uPAR-Expression in Colorectal Liver Metastases in Relation to Growth Pattern and Neo-adjuvant Therapy
Eefsen, Rikke Loevendahl; Engelholm, L.; Alpízar Alpízar, Warner; Van den Eynden, Gert G. E.; Vermeulen, Peter B.; Christensen, Ib J.; Laerum, Ole Didrik; Rolff, Hans Christian; Høyer Hansen, Gunilla; Vainer, B.; Osterlind, Kell; Illemann, Martin (2015-08-14)Proteolytic activity and inflammation in the tumour microenvironment affects cancer progression. In colorectal cancer (CRC) liver metastases it has been observed that three different immune profiles are present, as well ... -
Predictors of overall survival after surgery in gastric cancer patients from a Latin-American country
Cordero García, Eugenia; Ramos Esquivel, Allan Eduardo; Alpízar Alpízar, Warner (2017)Background: Gastric cancer is one of the major causes of cancer-related deaths in several Latin-American countries, including Costa Rica. However, determinants of poor outcomes are fairly unknown for patients from this ... -
The Neutrophil-Lymphocyte Ratio is an Independent Prognostic Factor for Overall Survival in Hispanic Patients with Gastric Adenocarcinoma
Ramos Esquivel, Allan Eduardo; Cordero García, Eugenia; Brenes Redondo, Dennis; Alpízar Alpízar, Warner (2018-07-13)Introduction High values of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are related with poor prognosis in patients with gastric cancer. However, this association has been rarely assessed in ... -
Tissue Inhibitor of Metalloproteinase-1 Is Confined to Tumor-Associated Myofibroblasts and Is Increased With Progression in Gastric Adenocarcinoma
Alpízar Alpízar, Warner; Didrik Laerum, Ole; Christensen, Ib J.; Ovrebo, Kjell; Skarstein, Arne; Høyer Hansen, Gunilla; Ploug, Michael; Illemann, Martin (2016)The tissue inhibitor of metalloproteinase-1 (TIMP-1) inhibits the extracellular matrix–degrading activity of several matrix metalloproteinases, thereby regulating cancer cell invasion and metastasis. Studies describing the ...