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Bactericidal activity of Lys49 and Asp49 myotoxic phospholipases A2 from Bothrops asper snake venom: synthetic Lys49 myotoxin II-(115-129)-peptide identifies its bactericidal region
(1998)
Mammalian group-II phospholipases A2 (PLA2) of inflammatory fluids display bactericidal properties,
which are dependent on their enzymatic activity. This study shows that myotoxins II (Lys49) and III
(Asp49), two group-II ...
Secretory phospholipases A2 isolated from Bothrops asper and from Crotalus durissus terrificus snake venoms induce distinct mechanisms for biosynthesis of prostaglandins E2 and D2 and expression of cyclooxygenases
(2008-09-01)
The effects of myotoxin III (MT-III), a phospholipase A2 (sPLA2) from Bothrops asper snake venom, and crotoxin B (CB), a neurotoxic and myotoxic sPLA2 from the venom of Crotalus durissus terrificus, on cyclooxygenases ...
Neutralizing properties of Varespladib toward group I and II myotoxic phospholipases A2
(2019)
A need exists to develop specific and clinically useful inhibitors of toxic enzymes present in snake venoms,
responsible for severe tissue damage and life-threatening effects occurring in thousands of people suffering
...
Ending the drought: New strategies for improving the flow of affordable, effective antivenoms in Asia and Africa
(2011-08-24)
The development of snake antivenoms more than a century ago should have heralded effective treatment of the scourge of snakebite envenoming in impoverished, mostly rural populations around the world. That snakebite still ...
Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide
(2004-03)
Snakebites constitute a serious public health problem in Central and South America, where species of the lancehead pit vipers (genus Bothrops) cause the majority of accidents. Bothrops envenomations are very painful, and ...
Neutrophils do not contribute to local tissue damage, but play a key role in skeletal muscle regeneration, in mice injected with Bothrops asper snake venom
(2003-10)
Local tissue damage induced by crotaline snake venoms includes edema, myonecrosis, hemorrhage, and an inflammatory response associated with a prominent cellular infiltrate. The role of neutrophils in the local tissue damage ...
What’s in a mass
(2021-04)
This short essay pretends to make the reader reflect on the concept of biological mass and on the added value that the determination of this molecular property of a protein brings to the interpretation of evolutionary and ...
Susceptibilidad de Trypanosoma cruzi a diferentes venenos de serpientes de Costa Rica
Susceptibility of Trypanosoma cruzi to different Costa Rican snake venoms
(2008)
Se evaluaron los efectos tóxicos de los venenos de cinco serpientes costarricenses en
cuanto a su capacidad tripanocida contra dos cepas de Trypanosoma cruzi y sus efectos en cuanto
a los mecanismos de muerte celular. ...
Snake Venomics of the Lesser Antillean Pit Vipers Bothrops caribbaeus and Bothrops lanceolatus: Correlation with Toxicological Activities and Immunoreactivity of a Heterologous Antivenom
(2008-10)
The venom proteomes of the snakes Bothrops caribbaeus and Bothrops lanceolatus, endemic to the
Lesser Antillean islands of Saint Lucia and Martinique, respectively, were characterized by reversephase
HPLC fractionation, ...
Medicinal plants with inhibitory properties against snake venoms
(2005)
Envenomations due to snake bites are commonly treated by parenteral administration of horse or
sheep-derived polyclonal antivenoms aimed at the neutralization of toxins. However, despite the widespread
success of this ...