Listar Microbiología por título
Mostrando ítems 733-752 de 1169
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Molecular determinants of antibiotic tolerance in the high-risk Pseudomonas aeruginosa AG1 by a multi-omics approach: from the genome to the transcriptomic network in response to ciprofloxacin
(2020)La resistencia a los antibióticos es una amenaza importante para la salud pública porque compromete la administración de una terapia antibiótica adecuada. Pseudomonas aeruginosa es un patógeno oportunista que causa infecciones ... -
Molecular epidemiology and antimicrobial resistance of Clostridium difficile in a national geriatric hospital in Costa Rica
(2018-08)Background: the epidemiology of Clostridium difficile infections (CDI) is changing rapidly worldwide; knowledge on the genotypes of C. difficile circulating in specialized geriatric hospitals and their resistance to ... -
Molecular epidemiology of Clostridium difficile infection in a Brazilian cancer hospital
(2017)Clostridium difficile is a Gram-positive spore forming anaerobic bacterium and the main cause of healthcare-associated diarrhea. This study aimed to perform the phenotypic characterization and molecular typing of Clostridium ... -
Molecular Recognition of Surface Trans-Sialidases in Extracellular Vesicles of the Parasite Trypanosoma cruzi Using Atomic Force Microscopy (AFM)
(2022-06-28)Trans-sialidases (TS) are important constitutive macromolecules of the secretome present on the surface of Trypanosoma cruzi (T. cruzi) that play a central role as a virulence factor in Chagas disease. These enzymes have ... -
Mortality by Hymenoptera stings in Costa Rica, 1985-2006
(2009)Objective. To analyze mortality due to Hymenoptera stings in Costa Rica during 1985–2006. Methods. Records of deaths due to Hymenoptera stings in 1985–2006 were retrieved from Instituto Nacional de Estadística y Censos ... -
Mortality due to snakebite envenomation in Costa Rica (1993–2006)
(2008-09-01)The mortality due to snakebite envenomation in Costa Rica for the period 1993–2006 was investigated by a retrospective analysis. There were 48 fatalities due to snakebites during this period. Mortality rates ranged from ... -
Multidrug‑Resistant Escherichia coli in Costa Rican Domestic Wastewater Treatment Plants Maintains Horizontal Transfer Capacity of Resistance Determinants in Effluents
(2023-06-13)This study was conducted to evidence the dissemination potential of antibiotic resistance genetic elements in E. coli isolates of Costa Rican domestic wastewater treatment plants (WWTPs). Few studies have addressed ... -
Multiple paths to aquatic specialisation in four species of Central American Anolis lizards
(2015-02-26)Aquatic anoles present an interesting ecomorphological puzzle. On the one hand, the link between habitat use and morphology is well established as convergent within the Caribbean anole radiation. On the other hand, aquatic ... -
Muscle phospholipid hydrolysis by Bothrops asper Asp49 and Lys49 phospholipase A2 myotoxins – distinct mechanisms of action
(2013-07-12)Bothrops snakes are the major cause of ophidian envenomings in Latin America. Their venom contains myotoxins that cause prominent muscle damage, which may lead to permanent disability. These toxins include myotoxins Mt-I ... -
Muscle Tissue Damage Induced by the Venom of Bothrops asper: Identification of Early and Late Pathological Events through Proteomic Analysis
(2016-04-01)The time-course of the pathological effects induced by the venom of the snake Bothrops asper in muscle tissue was investigated by a combination of histology, proteomic analysis of exudates collected in the vicinity of ... -
Mutual enlightenment: A toolbox of concepts and methods for integrating evolutionary and clinical toxinology via snake venomics and the contextual stance
(2021-07)Snakebite envenoming is a neglected tropical disease that may claim over 100,000 human lives annually worldwide. Snakebite occurs as the result of an interaction between a human and a snake that elicits either a defensive ... -
MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer
(2021-12-17)We hypothesize that dosage compensation of critical genes arises from systems- level properties for cancer cells to withstand the negative effects of aneuploidy. We identified several candidate genes in cancer multiomics ... -
Myonecrosis induced in mice by a basic myotoxin isolated from the venom of the snake Bothrops nummifer (jumping viper) from Costa Rica
(1989)The mode of action of a basic myotoxin isolated from Bothrops nummifer venom was studied. This myotoxin is a basic polypeptide of 13,000 mol.wt, with a high content of lysine and aspartate, as well as of hydrophobic amino ... -
Myotoxic and cytolytic activities of dimeric Lys49 phospholipase A2 homologues are reduced, but not abolished, by a pH-induced dissociation
(2005-09-01)Lys49 phospholipase A2 (PLA2) homologues are myotoxic proteins devoid of catalytic activity. Their toxic determinants map to the C-terminal region 115–129, which plays an effector role in membrane damage. The dimeric state ... -
Myotoxic phospholipases A2 in Bothrops snake venoms: Effect of chemical modifications on the enzymatic and pharmacological properties of bothropstoxins from Bothrops jararacussu
(2000-08)Venoms from eight Bothrops spp. were fractionated by ion-exchange chromatography on CM-Sepharose at pH 8.0 for the purification of myotoxins. Chromatographic profiles showed differences regarding myotoxic components among ... -
Myotoxin II from Bothrops asper (Terciopelo) venom is a lysine-49 phospholipase A2
(1991)A basic, dimeric myotoxic protein, myotoxin II, purified from Bothrops asper venom has a similar molecular weight and is immunologically cross-reactive with antibodies raised to previously isolated B. asper phospholipases ... -
Myotoxin-neutralizing peptides
(2018-03-27)The present invention relates to polypeptides having myotoxin-neutralizing properties and their use for treatment of envenomation. The present invention further relates to methods for neutralizing a venom using the polypeptide ... -
N-Formyl-Perosamine Surface Homopolysaccharides Hinder the Recognition of Brucella abortus by Mouse Neutrophils
(2016-06)Brucella abortus is an intracellular pathogen of monocytes, macrophages, dendritic cells, and placental trophoblasts. This bacterium causes a chronic disease in bovines and in humans. In these hosts, the bacterium also ... -
N-terminal peptide of myotoxin II from Bothrops asper venom enhances the activity of endothelin converting enzyme and neprilysin
(2016)Neprilysin (NEP) and endothelin converting enzyme-1 (ECE-1) are two enzymes that degrade amyloid beta in the brain. Currently there are no molecules to stimulate the activity of these enzymes. Here we report, the discovery ...