Logo Kérwá
 

Analysis of commercially available snake antivenoms reveals high contents of endotoxins in some products

Simple item page
dc.creatorSolano Blanco, Gabriela
dc.creatorAinsworth, Stuart
dc.creatorSánchez Sánchez, Adriana
dc.creatorVillalta Arrieta, Mauren
dc.creatorSánchez, Paola
dc.creatorDurán Blanco, Gina
dc.creatorGutiérrez, José María
dc.creatorLeón Montero, Guillermo
dc.date.accessioned2025-11-18T19:51:37Z
dc.date.issued2024-03
dc.description.abstractAs injectable therapeutics, snake antivenoms must meet specifications for endotoxin content. The Limulus amebocyte lysate (LAL) test was used to evaluate the endotoxin content in several commercially available antivenoms released for clinical use. It was found that some products have endotoxin concentrations higher than the accepted limit for these contaminants. These results emphasize the need to include endotoxin determination as part of the routine evaluation of antivenoms by manufacturers and regulatory agencies.
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Microbiología
dc.description.sponsorshipVicerrectoría de Investigación, Universidad de Costa Rica/[741-A0-804]/UCR/Costa Rica
dc.description.sponsorshipVicerrectoría de Investigación, Universidad de Costa Rica/[741-C0-523]/UCR/Costa Rica
dc.identifier.citationhttps://www.sciencedirect.com/science/article/pii/S2590171024000043
dc.identifier.codproyecto741-A0-804
dc.identifier.codproyecto741-C0-523
dc.identifier.doihttps://doi.org/10.1016/j.toxcx.2024.100187
dc.identifier.issn2590-1710
dc.identifier.urihttps://hdl.handle.net/10669/103237
dc.language.isoeng
dc.rightsacceso restringido
dc.sourceToxicon: X, 21, 100187
dc.subjectEndotoxin
dc.subjectLimulus amebocyte lysate test
dc.subjectSnake antivenom
dc.subjectPyrogen
dc.titleAnalysis of commercially available snake antivenoms reveals high contents of endotoxins in some products
dc.typeartículo original

Files

License bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
3.5 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Microbiología