A biocomputational platform for the automated construction of large-scale mathematical models of miRNA-transcription factor networks for studies on gene dosage compensation

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dc.creatorAcón, Man Sai
dc.creatorSiles Canales, Francisco
dc.creatorMora Rodríguez, Rodrigo Antonio
dc.date.accessioned2017-07-18T20:45:07Z
dc.date.available2017-07-18T20:45:07Z
dc.date.issued2016-11-09
dc.description.abstractCancer complexity and resistance is mediated by cell-to-cell heterogeneity, which is the consequence of the enormous instability of its genetic material. It is unknown how cancer cells are able to withstand the effects of these alterations, while normal cells are typically very sensitive. We hypothesize that cancer requires specific type of stability to survive the enormous chromosomal alterations. This stability may be mediated by a group of genes, whose expression is tightly regulated to maintain viability through a process called gene dosage compensation. This mechanism could be mediated by systems-level properties of complex networks of microRNAs (miRNA) and transcription factors (TF), regulating gene expression despite changes in copy number. Therefore, we designed a biocomputational platform to automatically construct large-scale mathematical models regulating the expression of several candidate genes under dosage compensation. This platform has a broader potential application to other scientific questions involving miRNA and TF networks.es_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Enfermedades Tropicales (CIET)es_ES
dc.identifier.citationhttp://ieeexplore.ieee.org/document/7942348/
dc.identifier.doi10.1109/CONCAPAN.2016.7942348
dc.identifier.isbn978-1-4673-9579-3
dc.identifier.urihttps://hdl.handle.net/10669/30376
dc.language.isoen_USes_ES
dc.rightsacceso abierto
dc.sourceCentral American and Panama Convention (CONCAPAN XXXVI); 2016 IEEE 36thes_ES
dc.subjectMiRNAses_ES
dc.subjectGene dosage compensationes_ES
dc.subjectCanceres_ES
dc.subjectSystems biologyes_ES
dc.titleA biocomputational platform for the automated construction of large-scale mathematical models of miRNA-transcription factor networks for studies on gene dosage compensationes_ES
dc.typeartículo original

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Microbiología