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Applications of single-molecule vibrational spectroscopic techniques for the structural investigation of amyloid oligomers

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dc.creatorVu, Katrin Ha Phuong
dc.creatorBlankenburg, Gerhard Heinrich
dc.creatorLesser Rojas, Leonardo
dc.creatorChou, Chia-Fu
dc.date.accessioned2024-07-31T16:49:46Z
dc.date.available2024-07-31T16:49:46Z
dc.date.issued2022-09-30
dc.description.abstractAmyloid oligomeric species, formed during misfolding processes, are believed to play a major role in neurodegenerative and metabolic diseases. Deepening the knowledge about the structure of amyloid intermediates and their aggregation pathways is essential in understanding the underlying mechanisms of misfolding and cytotoxicity. However, structural investigations are challenging due to the low abundance and heterogeneity of those metastable intermediate species. Single-molecule techniques have the potential to overcome these difficulties. This review aims to report some of the recent advances and applications of vibrational spectroscopic techniques for the structural analysis of amyloid oligomers, with special focus on single-molecule studies.
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Ciencias Atómicas Nucleares y Moleculares (CICANUM)
dc.description.procedenceUCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Física
dc.description.sponsorshipAcademia Sinica/AS-IA-109-M04//China
dc.description.sponsorshipMinistry of Science and Technology/110-2124-M-001-003/MOST/Taiwan
dc.description.sponsorshipAir Force Office of Scientific Research/FA2386-21-1-4070/AFOSR/Estados Unidos
dc.description.sponsorshipAir Force Office of Scientific Research/FA9550-21-1-0430/AFOSR/Estados Unidos
dc.identifier.citationhttps://www.mdpi.com/1420-3049/27/19/6448
dc.identifier.doihttps://doi.org/10.3390/molecules27196448
dc.identifier.issn1420-3049
dc.identifier.urihttps://hdl.handle.net/10669/91918
dc.language.isoeng
dc.rightsacceso abierto
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceMolecules, 27: 6448
dc.subjectvibrational spectroscopy
dc.subjectamyloid oligomers
dc.subjectamyloid intermediates
dc.subjectprotein structure
dc.subjectsingle molecule
dc.subjectOligómeros amiloides
dc.subjectaplicaciones espectrocópicas
dc.subjectmétodos espectrocópicos
dc.subjectespectroscopia vibracional monomolecular
dc.subjectestudios monomoleculares
dc.subjectenfermedades metabólicas
dc.subjectenfermedades neurodegenerativas
dc.subjectneurodegenerativa diseases
dc.subjectmetabolic diseases
dc.titleApplications of single-molecule vibrational spectroscopic techniques for the structural investigation of amyloid oligomers
dc.typeartículo de revisión

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