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Mandibular gland proteomics of the Mexican alligator lizard, Abronia graminea, and the red-lipped arboreal alligator lizard, Abronia lythrochila

dc.creatorCalvete Chornet, Juan José
dc.creatorLomonte, Bruno
dc.creatorTena Garcés, Jordi
dc.creatorZollweg, Michael
dc.creatorDietrich, Mebs
dc.date.accessioned2024-08-07T19:46:36Z
dc.date.available2024-08-07T19:46:36Z
dc.date.issued2024-08-02
dc.description.abstractA useful approach to deepen our knowledge about the origin and evolution of venom systems in Reptilia has been exploring the vast biodiversity of this clade of vertebrates in search of orally produced proteins with toxic actions, as well as their corresponding delivery systems. The occurrence of toxins in anguimorph lizards has been demonstrated experimentally or inferred from reports of the toxic effects of the oral secretions of taxa within the Varanidae and Helodermatidae families. In the present study, we have focused on two alligator lizards of the Anguidae family, the Mexican alligator lizard, Abronia graminea, and the red-lipped arboreal alligator lizard, A. lythrochila. In addition, the fine morphology of teeth of the latter species is described. The presence of a conserved set of proteins, including B-type natriuretic peptides, cysteine-rich secretory proteins, group III phospholipase A2, and kallikrein, in submandibular gland extracts was demonstrated for both Abronia species. These proteins belong to toxin families found in oral gland secretions of venomous reptile species. This finding, along with previous demonstration of toxin-producing taxa in both paleo- and neoanguimorpha clades, provides further support for the existence of a handful of conserved toxin families in oral secretions across the 100+ million years of Anguimorpha cladogenesis.
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)
dc.description.sponsorshipUniversidad de Costa Rica/[]/UCR/Costa Rica
dc.description.sponsorshipMinisterio de Ciencia e Innovación/[BFU2020_PID2020-119593GB-I00]//España
dc.identifier.doihttps://doi.org/10.1016/j.toxicon.2024.108055
dc.identifier.issn0041-0101
dc.identifier.issn1879-3150
dc.identifier.urihttps://hdl.handle.net/10669/91963
dc.language.isoeng
dc.rightsacceso abierto
dc.sourceToxicon, 249: 108055
dc.subjectLizard
dc.subjectVenomics
dc.subjectmandibular gland
dc.subjectMexican alligator lizards
dc.subjectGreen arboreal alligator lizard
dc.subjectAbronia graminea
dc.subjectRed-lipped arboreal alligator lizard
dc.subjectAbronia lythrochila
dc.subjectMandibular gland proteomics
dc.titleMandibular gland proteomics of the Mexican alligator lizard, Abronia graminea, and the red-lipped arboreal alligator lizard, Abronia lythrochila
dc.typeartículo original

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