Palladium-Catalyzed One-Pot Conversion of Aldehydes and Ketones into 4‑Substituted Homopropargyl Alcohols and 5‑En-3-yn-1-ols

dc.creator	Umaña, Christian A.
dc.creator	Cabezas Pizarro, Jorge A.
dc.date.accessioned	2023-01-03T16:38:52Z
dc.date.available	2023-01-03T16:38:52Z
dc.date.issued	2017
dc.description.abstract	Sequential treatment of 2,3-dichloropropene with magnesium and n-BuLi generated the equivalent of 1,3- dilithiopropyne, which adds regiospecifically to aldehydes and ketones to produce homopropargyl alcohols. The lithium acetylide intermediate formed in this protocol can be further reacted with aromatic and vinyl halides, under palladium catalysis, to produce 4-substituted homopropargyl alcohols and 5-en-3-yn-1-ols, respectively, in one-pot with good overall yields.	es
dc.description.procedence	UCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Química	es
dc.identifier.citation	https://pubs.acs.org/doi/10.1021/acs.joc.7b01529
dc.identifier.doi	https://doi.org/10.1021/acs.joc.7b01529
dc.identifier.issn	0022-3263
dc.identifier.uri	https://hdl.handle.net/10669/87985
dc.language.iso	eng
dc.rights	acceso embargado
dc.source	J. Org. Chem. 2017, 82, 18, 9505–9514	es
dc.subject	Alcohols	es
dc.subject	Allenes	es
dc.subject	Aromatic compounds	es
dc.subject	Hydrocarbons	es
dc.subject	Palladium	es
dc.title	Palladium-Catalyzed One-Pot Conversion of Aldehydes and Ketones into 4‑Substituted Homopropargyl Alcohols and 5‑En-3-yn-1-ols	es
dc.type	artículo original	es

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