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Preclinical evaluation of three polyspecific antivenoms against the venom of Echis ocellatus: Neutralization of toxic activities and antivenomics

dc.creatorCalvete Chornet, Juan José
dc.creatorArias Oviedo, Ana Silvia
dc.creatorRodríguez, Yania
dc.creatorQuesada Bernat, Sarai
dc.creatorSánchez Céspedes, Laura Vanessa
dc.creatorChippaux, Jean Philippe
dc.creatorPla Ferrer, Davinia
dc.creatorGutiérrez, José María
dc.date.accessioned2017-06-08T16:13:09Z
dc.date.available2017-06-08T16:13:09Z
dc.date.issued2016-09-01
dc.description.abstractSnakebite envenoming has a heavy burden in the public health in sub-Saharan Africa. The viperid species Echis ocellatus (carpet viper or saw-scaled viper) is the medically most important snake in the savannahs of western sub-Saharan Africa. Several antivenoms are being distributed and used in this region for the treatment of envenomings by E. ocellatus, but the preclinical efficacy of some of these antivenoms has not been assessed. The present study evaluated the preclinical efficacy against E. ocellatus venom of three polyspecific antivenoms: (a) Snake Venom Antiserum (Pan Africa), manufactured by Premium Serums and Vaccines (India); (b) Snake Venom Antiserum (Africa), manufactured by VINS Bioproducts (India); and (c) Antivipmyn® Africa, manufactured by Instituto Bioclon (Mexico). Antivenomics analysis revealed the ability of the three antivenoms to immunocapture the majority of components of the venoms of E. ocellatus from Cameroon, Nigeria and Mali, although their maximal immunocapturing capability varied. Bioclon and Premium Serums antivenoms were effective in the neutralization of lethal, hemorrhagic and in vitro coagulant activities of the venom of E. ocellatus from Cameroon, albeit with different potencies. VINS antivenom neutralized hemorrhagic activity of this venom, but failed to neutralize lethality at the highest antivenom dose tested, and had a low neutralizing efficacy against in vitro coagulant effect.es_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-B4-524]/UCR/Costa Ricaes_ES
dc.description.sponsorshipMinisterio de Economía y Competitividad/[BFU2013-42833-P]//Españaes_ES
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0041010116301763
dc.identifier.doi10.1016/j.toxicon.2016.06.022
dc.identifier.issn0041-0101
dc.identifier.pmid27377229
dc.identifier.urihttps://hdl.handle.net/10669/30065
dc.language.isoen_USes_ES
dc.rightsacceso embargado
dc.sourceToxicon; Volumen 119. 2016es_ES
dc.subjectAfricaes_ES
dc.subjectEchis ocellatus venomes_ES
dc.subjectAntivenomses_ES
dc.subjectNeutralizationes_ES
dc.subjectAntivenomicses_ES
dc.subjectLethalityes_ES
dc.titlePreclinical evaluation of three polyspecific antivenoms against the venom of Echis ocellatus: Neutralization of toxic activities and antivenomicses_ES
dc.typeartículo original

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