507. Association of NRXN3 deletion with schizophrenia and bipolar disorder
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Shavit, Ayal
Gonzalez, Jessica
Chavez, Maricela
Rodriguez, Marco A.
Camarillo, Cynthia
Ramírez, Mercedez Ellis
Zavala, Juan Manuel
Contreras Rojas, Javier
Raventós Vorst, Henriette
Flores, Deborah Lynne
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Abstract
Schizophrenia (SZ) and bipolar disorder (BD) are the most severe neuropsychiatric disorders affecting 1.2% and 4.4% of Americans, respectively. Certain genes coding for proteins involved in pre-synaptic machinery are thought to play a role in the pathophysiology of the disorder. Deficits in the calcium channel regulator gene NRXN3 have been associated with behaviors of impulsivity and alcohol and drug dependence, which are traits characteristic of BD and SZ.
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Keywords
Schizophrenia, Bipolar Disorder, NRXN3