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846. Human-derived astrocytes from schizophrenia patients express lower levels of GFAP and S100B

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dc.creatorStertz, Laura
dc.creatorRaventós Vorst, Henriette
dc.creatorWalss Bass, Consuelo
dc.date.accessioned2024-11-26T14:33:58Z
dc.date.available2024-11-26T14:33:58Z
dc.date.issued2017-04-29
dc.description.abstractSchizophrenia (SZ) is a debilitating psychiatric disorder with a worldwide prevalence of 1%; there is a strong genetic component, with an estimated heritability of 70-85%. Glial cells mediate crucial functions in the CNS and alterations in the function of these cells may be an underlying mechanism for SZ development. Here we use astrocytes derived from induced pluripotent stem cells (iPSCs) from subjects from the population isolate of the Central Valley of Costa Rica (CVCR) to explore a role for astrocytes in SZ pathogenesis.
dc.description.procedenceUCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Biología
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Biología Celular y Molecular (CIBCM)
dc.description.sponsorshipUniversidad de Texas/[]/UT/Estados Unidos
dc.identifier.doihttps://doi.org/10.1016/j.biopsych.2017.02.571
dc.identifier.issn0006-3223
dc.identifier.issn1873-2402
dc.identifier.urihttps://hdl.handle.net/10669/100135
dc.language.isoeng
dc.rightsacceso restringido
dc.sourceBiological Psychiatry, 15, S342-S343
dc.subjecthIPSC
dc.subjectSchizophrenia
dc.subjectAstrocytes
dc.title846. Human-derived astrocytes from schizophrenia patients express lower levels of GFAP and S100B
dc.typeactas de congreso

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